Experimental evaluation of analgesic activity of PPAR γ agonists: pioglitazone and rosiglitazone

Authors

  • Chetanraj G. Bhamare Department of Pharmacology, S R T R Government Medical College, Ambajogai- 431517, Maharashtra, India
  • Sudhir L. Padwal Department of Pharmacology, S R T R Government Medical College, Ambajogai- 431517, Maharashtra, India
  • Vijay M. Motghare Department of Pharmacology, S R T R Government Medical College, Ambajogai- 431517, Maharashtra, India
  • Rushikesh P. Deshpande Department of Pharmacology, S R T R Government Medical College, Ambajogai- 431517, Maharashtra, India
  • Rakesh R. Pore Department of Pharmacology, S R T R Government Medical College, Ambajogai- 431517, Maharashtra, India
  • Suvarna S. Rathod Department of Pharmacology, S R T R Government Medical College, Ambajogai- 431517, Maharashtra, India
  • Harshal N. Pise Department of Pharmacology, S R T R Government Medical College, Ambajogai- 431517, Maharashtra, India

Keywords:

Analgesic activity, Pioglitazone, Rosiglitazone, Tail flick method, Acetic acid induced writhing method

Abstract

Background: To evaluate analgesic activity of pioglitazone and rosiglitazone by tail flick method in rats and acetic acid induced writhing method in mice.

Methods: Albino wistar rats of either sex weighing 180-200 g and Swiss mice weighing 25-30 g were used. Study was conducted after approval from the Institutional Animal Ethics Committee. The tail flick method in rats described by D’Amour and Smith (1941) and acetic acid induced writhing in mice were used. The dose of pioglitazone and rosiglitazone were 20 mg/kg and 10 mg/kg respectively.

Results: In tail flick method of analgesia, both, pioglitazone and rosiglitazone have analgesic activity which was statistically comparable to aspirin. In acetic acid induced writhing model of analgesia, the action of pioglitazone and rosiglitazone was significantly greater than the control group but it was less when compared to aspirin.

Conclusions: Analgesic activity of pioglitazone and rosiglitazone was comparable to aspirin in tail flick model of analgesia in rats while it was significantly less when compared to tramadol. Analgesic activity of pioglitazone and rosiglitazone was significantly less than aspirin in acetic acid induced writhing method.

References

Pain terms: a list with definitions and notes on usage. Recommended by the IASP Subcommittee on Taxonomy. Pain. 1979;6(3):249.

Rajagopal MR. Pain- Basic consideration. Indian J Anaesth. 2006;50(5):331-4.

Stuky CL, Gold MS, Zhang XU. Mechanism of pain. PNAS. 2001;98(21):1185-6.

Yki-Jarvinen H. Thiazolidinediones. N Engl J Med. 2004;351:1106–18.

Fehrenbacher JC, Lo Verme J, Clarke W, Hargreaves KM, Piomelli D, Taylor BK. Rapid Pain Modulation with Nuclear Receptor Ligands. Brain Res Rev. 2009;60:114-24.

Parmar NS, Prakash S. Evaluation of analgesics, anti-inflammatory and anti-pyretic activity. In: Parmar NS, editor. Screening Methods in Pharmacology. New Delhi, India: Narosa Publishing House; 2006: 232-233.

Parmar NS, Prakash S. Evaluation of analgesics, anti-inflammatory and anti-pyretic activity. In: Parmar NS, editor. Screening Methods in Pharmacology, New Delhi, India: Narosa Publishing House; 2006: 225-226.

Abdelrahman M, Sivarajah A, Thiemermann C. Beneficial effects of PPAR-gamma ligands in ischemia-reperfusion injury, inflammation and shock. Cardiovasc Res. 2005;65:772–81.

Jia H, Zhu S, Ji Q, Hui K, Duan M, Xu J, et al. Repeated Administration of Pioglitazone Attenuates Development of Hyperalgesia in a Rat Model of Neuropathic Pain. Exp Clin Psychopharmacol. 2010;18(4):359-65.

Churi SB, Abdel-Aleem OS, Tumber KK, Scuderi-Porter H, Taylor BK. Intrathecal Rosiglitazone Acts at Peroxisome Proliferator–Activated Receptor-γ to Rapidly Inhibit Neuropathic Pain in Rats. J Pain. 2008;9(7):639-49.

Vogel HG. Analgesic, Anti-inflammatory and anti-pyretic activity. In: Vogel HG, editor. Drug Discovery and Evaluation: Pharmacological Assays. 2nd ed. Berlin Germany: Springer-Verlag Publications; 2002: 767.

Oliveira AC, Bertollo CM, Rocha LT, Nascimento EB Jr, Costa KA, Coelho MM. Antinociceptive and antiedematogenic activities of fenofibrate, an agonist of PPAR alpha, and pioglitazone, an agonist of PPAR gamma. Eur J Pharmacol. 2007;561(1-3):194 201.

Downloads

Published

2017-01-23

How to Cite

Bhamare, C. G., Padwal, S. L., Motghare, V. M., Deshpande, R. P., Pore, R. R., Rathod, S. S., & Pise, H. N. (2017). Experimental evaluation of analgesic activity of PPAR γ agonists: pioglitazone and rosiglitazone. International Journal of Basic & Clinical Pharmacology, 3(1), 86–91. Retrieved from https://www.ijbcp.com/index.php/ijbcp/article/view/952

Issue

Section

Original Research Articles