Analgesic and anti-inflammatory properties of the aqueous extract leaves of Murraya koenigii linn in small animal models

Authors

  • Madhavulu Buchineni Department of Pharmacology, Narayana Medical College, Nellore, Andhra Pradesh, India
  • N. Ravi Department of Pharmacology, Narayana Medical College, Nellore, Andhra Pradesh, India
  • B. L. Kudagi Department of Pharmacology, Narayana Medical College, Nellore, Andhra Pradesh, India
  • R. Pravin Kumar Department of Pharmacology, Narayana Medical College, Nellore, Andhra Pradesh, India
  • Rama Mohan Pathapati Department of Pharmacology, Narayana Medical College, Nellore, Andhra Pradesh, India
  • Chandra Bhopal Department of Pharmacology, Narayana Medical College, Nellore, Andhra Pradesh, India

Keywords:

Murraya koenigii linn, Anti-inflammatory, Analgesic, Tail flick method, Hot plate, Ibuprofen, Carrageenan

Abstract

Background: The present study was carried out to evaluate the analgesic activity of aqueous extract leaves of Murraya koenigii linn in Albino rats using tail flick method, Eddy’s hot plate methods and anti-inflammatory activity in Carrageenan induced paw edema in rats.

Methods: The analgesic activity was evaluated using Eddy’s hot plate induced hyperalgesia and tail flick method, which served as thermal induced pain, where the animal were placed on the hot plate and the reaction time to (lick the paw/jump out) from the hot plate was observed, 0, 30, 60, 90 mins. Murraya 300 mg, 600 mg/kg/body weight (BW) and ibuprofen (5 mg/kg BW) was administered per oral. The anti-inflammatory activity was measured by Carrageenan induced paw edema volumes at 0, 1, 2, 3 and 4 hrs using mercury plethysmometer, which served as chemical induced pain models.

Results:  The mean reaction time in Murraya at a dose of 600 mg/kg at 0 min 5.45±0.72, at 30 mins 6.52±1.03, at 60 mins 7.6±0.81, at 90 mins 8.8±0.63 respectively. The mean reaction time increased significantly with Murraya at dose of 600 mg/kg when compared with control.

In the ibuprofen group, the mean reaction time at 0 hr was 0.28±0.04, at 1 hr 0.34±0.05, at 2 hrs 0.46±0.03, at 3 hrs 0.61±0.05, at 4 hrs 0.76±0.05. The mean reaction time Murraya in group 600 mg/kg at 0 hr 0.27±0.04, at 1 hrs 0.39±0.03, at 2 hrs 0.48±0.06, at 3 hrs 0.68±0.05, at 6 hrs 0.80±0.03, respectively.

Conclusions: The results indicate that the aqueous extract of Murraya (leaf) extract revealed significant analgesic and anti-inflammatory in thermal and chemical induced pain models.

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Published

2017-01-20

How to Cite

Buchineni, M., Ravi, N., Kudagi, B. L., Kumar, R. P., Pathapati, R. M., & Bhopal, C. (2017). Analgesic and anti-inflammatory properties of the aqueous extract leaves of Murraya koenigii linn in small animal models. International Journal of Basic & Clinical Pharmacology, 4(1), 41–45. Retrieved from https://www.ijbcp.com/index.php/ijbcp/article/view/861

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Original Research Articles