Can occupational exposure to antineoplastic drugs increase levels of an inflammatory trigger?

Authors

  • T. Kamalasundar Department of Pharmacology, Father Muller Medical College, Mangalore, Karnataka, India
  • Padmaja Udaykumar Department of Pharmacology, Father Muller Medical College, Mangalore, Karnataka, India
  • Prabin Shah Department of Biochemistry, Father Muller Medical College, Mangalore, Karnataka, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20150368

Keywords:

Antineoplastic drugs, Nurses, Advanced oxidation protein products, Protein oxidation

Abstract

Background: Antineoplastic drugs (AND) are known to cause collateral damage to normal cells by oxidative stress. This study was conducted to check for oxidative stress in occupational exposure to these drugs using advanced oxidation protein products (AOPP).

Methods: Cross-sectional comparison of serum AOPP levels of 33 nurses occupationally exposed and serum AOPP levels of 30 nurses not exposed using modified AOPP method.

Results: Serum AOPP levels were significantly increased (p<0.001) in the exposed group (16.66±3.31) compared to the unexposed group (12.87±2.62).

Conclusion: This study highlights oxidative stress in the form of protein oxidation occurring in nurses exposed to AND.

References

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Published

2017-01-19

How to Cite

Kamalasundar, T., Udaykumar, P., & Shah, P. (2017). Can occupational exposure to antineoplastic drugs increase levels of an inflammatory trigger?. International Journal of Basic & Clinical Pharmacology, 4(4), 660–663. https://doi.org/10.18203/2319-2003.ijbcp20150368

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Section

Original Research Articles