To study the efficacy and safety of Vitamin D as an add-on therapy in patients of Type 2 diabetes mellitus on oral antidiabetic drugs

Authors

  • Ravneet K. Sandhu Department of Pharmacology, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, India
  • Geeta Sharma Department of Pharmacology, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, India
  • Satya B. Nayyar Department of Medicine, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, India
  • Meenakshi Gupta Department of Pharmacology, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20151372

Keywords:

Diabetes mellitus, Vitamin D deficiency, Vitamin D

Abstract

Background: Predominance of Type 2 diabetes mellitus (DM) is increasing globally at an alarming rate. Therapies for Type 2 DM have improved but still there is a need for new insights to limit the progression of the disease. Vitamin D deficiency has been associated with many non-skeletal disorders including Type 2 DM, suggesting a role in pathogenesis of Type 2 DM. Therefore, the present study was designed to investigate the effect of Vitamin D as an add-on therapy in patients of Type 2 DM whose glycemic status was uncontrolled with oral antidiabetic drugs.

Methods: This was a before and after, open labeled study of 12 weeks duration, conducted on 50 patients of Type 2 DM and Vitamin D deficiency. These patients were given 60,000 IU of Vitamin D3 orally/week for 12 weeks in addition to oral antidiabetic drugs. Effect of Vitamin D was observed on HbAIC, fasting blood glucose (FBG), 25(OH)D and calcium levels.

Results: At the end of 12 weeks, a highly significant reduction (p<0.001) was seen in FBG levels and HbAIC decreased significantly (p<0.05). Highly significant (p<0.001) increase was observed in 25(OH)D levels and calcium levels increased significantly (p<0.05). No untoward side effect was observed in any of the patients.

Conclusion: It establishes that Vitamin D therapy improves glycemic status thereby, delays the progression and consequently the complications of Type 2 DM. Therefore, supplementation of Vitamin D is a promising and safe adjuvant therapy in Vitamin D deficient Type 2 DM patients.

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Published

2017-01-16

How to Cite

Sandhu, R. K., Sharma, G., Nayyar, S. B., & Gupta, M. (2017). To study the efficacy and safety of Vitamin D as an add-on therapy in patients of Type 2 diabetes mellitus on oral antidiabetic drugs. International Journal of Basic & Clinical Pharmacology, 4(6), 1276–1280. https://doi.org/10.18203/2319-2003.ijbcp20151372

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