A comparative study of efficacy of argyreia speciosa and orlistat for their anti-obesity action in high fat diet induced obese rats

Authors

  • Suhas H. Patil Department of Pharmacology, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Pimpri, Pune 411018, Maharashtra, India
  • Satkar Rajbhoj Department of Pharmacology, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Pimpri, Pune 411018, Maharashtra, India
  • Seema V. Bhalerao Department of Pharmacology, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Pimpri, Pune 411018, Maharashtra, India
  • Puja Jha Department of Pharmacology, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Pimpri, Pune 411018, Maharashtra, India
  • Manasi V. Limaye Department of Pharmacology, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Pimpri, Pune 411018, Maharashtra, India
  • Mohanish U. Vaidya Department of Pharmacology, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Pimpri, Pune 411018, Maharashtra, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20170823

Keywords:

Anti-obesity, Argyreia speciosa, Cafeteria diet, Orlistat

Abstract

Background: To compare the anti-obesity action of Argyreia speciosa root extract with standard anti-obesity drug orlistat. Healthy Sprague-Dawley rats (100-200g, n=50) were obtained from the animal house. Dose of Orlistat was 32.4mg/kg/day and Dose of Argyreia speciosa root was 500mg/kg/day.

Methods: Food induced obesity model was used. Following parameters were evaluated: Total Cholesterol (mg/dl), Triglyceride (mg/dl), HDL-cholesterol (mg/dl), LDL cholesterol (mg/dl), atherogenic index, serum lipase (U/L). Analysis was done by one way ANOVA followed by post-hoc test and Graph Pad Prism version 5.00 was used for the analysis.

Results: Total cholesterol, triglcerides, LDL cholesterol and Atherogenic index was significantly lesser in the rats fed with CD+O group and CD+ASE group than in the animals from CD group (p<0.05). It was also significantly lesser in the rats fed with CD+O+ASE than in the animals from CD group (p<0.05). HDL cholesterol was significantly greater in the rats fed with CD+O group and CD+ASE group than in the animals from CD group (p<0.05). It was also significantly greater in the rats fed with CD+O+ASE than in the animals from CD group (p<0.05).

Conclusions: ASE significantly reduces total cholesterol (mg/dl), triglyceride (mg/dl), LDL cholesterol (mg/dl) and atherogenic index, it significantly increases HDL- cholesterol (mg/dl) and it is comparable to orlistat. Thus the anti-obesity action of ASE is comparable to orlistat.

References

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Kumar S, Alagawadi KR, Rao MR. Effect of Argyreia speciosa root extract on cafeteria diet-induced obesity in rats. Indian J Pharmacol. 2011;43:163-7.

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Published

2017-02-24

How to Cite

Patil, S. H., Rajbhoj, S., Bhalerao, S. V., Jha, P., Limaye, M. V., & Vaidya, M. U. (2017). A comparative study of efficacy of argyreia speciosa and orlistat for their anti-obesity action in high fat diet induced obese rats. International Journal of Basic & Clinical Pharmacology, 6(3), 613–617. https://doi.org/10.18203/2319-2003.ijbcp20170823

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Original Research Articles