Drug utilization study in patients with type 2 diabetes mellitus attending diabetes clinic of a tertiary care hospital in rural Bengal

Authors

  • Sekhar Mandal Department of Pharmacology,Bankura Sammilani Medical College, Bankura, India
  • Tamoghna Maiti Department of Pharmacology,Bankura Sammilani Medical College, Bankura, India
  • Asoke Kr. Das Department of Pharmacology,Bankura Sammilani Medical College, Bankura, India
  • Abhijit Das Department of Pharmacology,Bankura Sammilani Medical College, Bankura, India
  • Ananya Mandal Department of Pharmacology,Bankura Sammilani Medical College, Bankura, India
  • Biswanath Sharma Sarkar Department of Medicine, Bankura Sammilani Medical College, Bankura, India
  • Soumitra Mandal Department of Pharmacology,Bankura Sammilani Medical College, Bankura, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20162487

Keywords:

Diabetes mellitus, Drug utilization, Metformin

Abstract

Background: Diabetes mellitus (DM) is a common and important health problem affecting the citizens of developed as well as developing nations. Not only does it require long term therapy, it is also crippling in terms of cost of management. Drug utilization studies help to determine rational drug use especially in poorer and rural populations. The objective of this study was to evaluate drug utilization pattern in type-2 diabetes patients in a diabetic clinic of a tertiary care teaching hospital in rural Bengal.

Methods: This was a prospective observational study including 181 patients for a period of 6 months in Bankura Sammilani Medical College. Patients diagnosed as type 2 diabetes mellitus were included in the study. The demographic data, disease data and utilization of different classes of oral hypoglycaemic agents and insulin as well as other individual drugs were analysed using the World Health Organization (WHO) indicators for drug utilization studies.

Results: The study population was predominantly male (61.33%) and nearly a third (30.9%) belonged to the age group of 50-59 years. Co-morbid conditions were found in 74% patients, among which hypertension (51.1%) was the most common co-morbid condition. The average number of drugs per prescription was 4.22 and the average number of antidiabetic drugs per prescription was 2.18. Metformin was the most commonly prescribed drug (79.6%), followed by sulfonylurea class of drugs (66.9%). Nearly 17.7% patients were on insulin preparations. Glimepiride and metformin was the most common combinations used (45.5%). Antibiotics were included in 15.5% prescriptions and proton pump inhibitors were prescribed in 32% cases. All the medicines were prescribed as generics and injections were prescribed in 17.7% cases.

Conclusions: This study gives a picture of the pattern of drug use among diabetes patients in our set up. While metformin was the commonest drug used, glimepiride and metformin combination was the commonest combination therapy.

References

Introduction to Drug Utilization Research. Oslo, Norway. WHO; 2003:1-73.

Sachdeva PD, Patel BG. Drug utilization studies- scope and future perspectives. International Journal on Pharmaceutical and Biological Research. 2010;1:11-7.

American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2012;35(Suppl 1):64-71.

IDF Diabetes Atlas. 6th ed. International Diabetes Federation, 2013. Available at http://www.idf.org. Accessed on July 2015.

King H, Aubert RE, Herman WH. Global burden of diabetes, 1995. 2025: prevalence, numerical estimates, and projections. Diabetes Care. 1998;21:1414-31.

Unger J. Current strategies for evaluating, monitoring, and treating type 2 diabetes mellitus. Am J Med. 2008;121(Suppl 6):S3-8.

Krentz AJ, Bailey CJ. New drugs for type 2 diabetes: What is their place in therapy? Drugs. 2008;68:2131-62.

El-Kaissi S, Sherbeeni S. Pharmacological management of type 2 diabetes mellitus: an update. Curr Diabetes Rev. 2011;7:392-405.

American Diabetes Association. Standards of medical care in Diabetes-2015. Diabetes care. 2015;38(Suppl 1):S41-8.

Who Asia Pacific perspective for Asians (WHO IOTF 2003). Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet. 2004;363:157-63.

Rani J, Reddy S. Prescribing pattern of antidiabetic drugs in urban population of Hyderabad. Natl J Physiol Pharm Pharmacol. 2015;5:5-9.

Sudha V, Shukla P, Patidar P. Prescribing pattern of antidiabetic drugs in Indore city hospital Indian. Journal of Pharmaceutical Sciences. 2008;70:637-40.

Boccuzzi SJ, Wogen J, Fox J. Utilization of oral hypoglycemic agents in a drug-insured U.S. Population. Diabetes Care. 2004;24:1411-5.

Johnson JA, Pohar SL, Secnik K. Utilization of diabetes medication and cost of testing supplies in Saskatchewan, 2001. BMC Health Serv Res. 2006;6:159.

Yurgin N, Secnik K, Lage MJ. Antidiabetic prescriptions and glycemic control in German patients with type 2 diabetes mellitus: a retrospective database study. Clin Ther. 2007;29:316-25.

Dutta S, Beg MA, Anjoom M, Varma A, Bawa S. Study of prescribing pattern in diabetes mellitus patients in a tertiary care teaching hospital at Dehradun, Uttarakhand. Int J Med Sci Public Health. 2014;3:1351-4.

Adibe MO, Aguwa CN, Ukwe CV, Okonta JM, Udeogaranya PO. Outpatient utilization of anti-diabetic drugs in the South Eastern Nigeria. Int J Drug Dev and Res. 2009;1:27-36.

John LJ, Arifulla M, Sreedharan J, Muttappallymyalil J, Das R, John J et al. Age And Gender-Based Utilization Pattern of Antidiabetic Drugs In Ajman, UAE. Malaysian J of Pharm Sci. 2012;10:79-85.

Abdi SAH, Churi S, Kumar YSR. Study of drug utilization pattern of antihyperglycemic agents in a South Indian tertiary care teaching hospital. Indian J Pharmacol. 2012; 44:210-4.

Guerci1 B, Drouin P. Self-monitoring of blood glucose significantly improves metabolic control in patients with type 2 diabetes mellitus: the Auto-Surveillance Intervention Active (ASIA) study diabetes Metab 2003; 29:587-94.

Mastura I, Chew BH, Lee PY, Cheong AT, Sazlina SG, Jamaiyah H, et al. Control and Treatment Profiles of 70,889 Adult Type 2 Diabetes Mellitus Patients in Malaysia - A Cross Sectional Survey in 2009. International Journal of Collaborative Research on Internal Medicine & Public Health 2011; 3:98-113.

Vengurlekar S, Shukla P, Patidar P, Bafna R, Jain S. Prescribing pattern of antidiabetic drugs in Indore city hospital. Indian J Pharm Sci 2008; 70:637-40.

Dhanraja E, Raval AD, Yadav R, Bhansali A, Tiwari P. Prescribing pattern of antidiabetic drugs and achievement of glycemic control in T2DM patients in tertiary care hospital in North India. International Journal of Diabetes in Developing Countries 2013:33:140-6.

Barnett AH. Redefining the role of thiazolidinediones in the management of type 2 diabetes. Vasc Health Risk Manag. 2009;5(1):141-51.

Patel B, Oza B, Patel KP, Malhotra SD, Patel VJ. Pattern of antidiabetic drugs use in type-2 diabetic patients in a medicine outpatient clinic of a tertiary care teaching hospital. Int J Basic Clin Pharmacol. 2013;2:485-91.

Dave DJ, Dikshit RK, Gandhi AM. Utilization of some newer oral antidiabetic agents in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. 2012;2:146-51.

Jimoh AO, Sabir AA, Chika A, Sani Z. Pattern of Antidiabetic drugs use in a diabetic outpatient clinic of a tertiary health institution in Sokoto, North-western Nigeria. Journal of Medical Sciences. 2011;11:241-5.

Kumar MA, Nizar A, Shailaja K, Jayasutha J, Ramasamy C. A study on prescribing pattern and potential drug-drug interactions in type 2 diabetes mellitus in a tertiary care teaching hospital. Der Pharmacia Lettre. 2011:3:13-9.

Arshad K, Kumar S. A study on drug utilization of oral hypoglycemic agents in type-2 diabetic patients. Asian J Pharm Clin Res. 2011;4:60-4.

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Published

2017-01-05

How to Cite

Mandal, S., Maiti, T., Das, A. K., Das, A., Mandal, A., Sarkar, B. S., & Mandal, S. (2017). Drug utilization study in patients with type 2 diabetes mellitus attending diabetes clinic of a tertiary care hospital in rural Bengal. International Journal of Basic & Clinical Pharmacology, 5(4), 1647–1654. https://doi.org/10.18203/2319-2003.ijbcp20162487

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Original Research Articles