Association of body mass index, hand grip strength and quality of life with response to anti-tubercular therapy in adult patients of pulmonary and extra-pulmonary tuberculosis

Authors

  • Prashant Mishra Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India; Department of Pharmacology, Armed Force Medical College, Pune, Maharashtra, India
  • Vipin Kumar Verma Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India
  • Meenakshi Meenu Department of Pharmacology, All India Institute of Medical Sciences, Bilaspur, Himachal Pradesh, India
  • Anant Mohan Department of Pulmonary Medicine and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India
  • Jagriti Bhatia Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India
  • Dharamvir Singh Arya Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20214121

Keywords:

Tuberculosis, BMI, HGS, WHOQOL-BREF, ATT

Abstract

Background: Monitoring of anti-tubercular therapy (ATT) response necessary for successful completion of ATT regimen. Presently available monitoring tools are invasive and have limitations. This study undertaken to see whether non-invasive tools like body mass index (BMI), hand grip strength (HGS) and quality of life (QOL) can serve as a reliable tool for monitoring ATT response.

Methods: The 50 patients of tuberculosis were monitored for BMI, HGS and QOL via WHOQOL-BREF questionnaire and analyzed at baseline, 2 months and 6 months of starting ATT.

Results: BMI HGS increased significantly at 2 months and 6 months compared to baseline with ATT. Physical and social domain of WHOQOL-BREF increased at 2 and 6 months with ATT, other domains shown no significant changes.

Conclusions: Monitoring of BMI, handgrip strength and QOL can be a cost-effective tool for monitoring ATT response, both in pulmonary and extra pulmonary tuberculosis.

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Published

2021-10-22

How to Cite

Mishra, P., Verma, V. K., Meenu, M., Mohan, A., Bhatia, J., & Arya, D. S. (2021). Association of body mass index, hand grip strength and quality of life with response to anti-tubercular therapy in adult patients of pulmonary and extra-pulmonary tuberculosis. International Journal of Basic & Clinical Pharmacology, 10(11), 1297–1307. https://doi.org/10.18203/2319-2003.ijbcp20214121

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Original Research Articles