DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20212083

An evaluation of knowledge, attitude and perception about adverse drug reactions and pharmacovigilance among intern doctors in a medical college teaching hospital of Sangli

Santoshkumar A. Shetti, R. P. Limaye

Abstract


Background: Underreporting of various adverse drug reactions (ADRs) by consultants is a common incurable problem. National pharmacovigilance program is one of the ongoing programs to monitor the adverse drug reactions & reporting at the earliest to the nearby AMCs. As medical interns are budding doctors, the focus of this study was to evaluate the knowledge, attitude and perception about ADRs and pharmacovigilance in them.

Methods: A cross section questionnaire-based study was conducted after approval by our institutional ethics committee pretested and validated questions consisting of 20 questions (knowledge, attitude, perception) were administrated to medical interns. The filled questionnaires were collected and analysed.

Results: In our study, medical interns have fair enough idea about ADR and pharmacovigilance. In knowledge domain they were aware of term ADRs (100%), pharmacovigilance (72.6%). In attitude domain majority of interns (80.6%) known availability of ADR forms, compulsory of pharmacovigilance unit (90.3%). In perception domain very poor response from interns, not even a single intern had reported any ADR filled form and they don’t know meaning of re-challenge and de-challenge, very few interns (9.7%) know how to manage the ADRs in emergency conditions.

Conclusions: Under reporting problem can be improved by doing more teaching activities at undergraduate level and intern’s level including various workshops, CMEs, problem-based teaching of adverse reactions in their curriculum. These exercises will improve their reporting frequency and sensitize the interns from the undergraduate days itself in their upcoming clinical practice in community.


Keywords


Pharmacovigilance, Adverse drug reactions, Intern, Knowledge

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References


Brown SD, Landry FJ. Recognizing, reporting and reducing adverse drug reactions. South Med J. 2001;94:370-3.

Sriram S, Ghasemi A, Ramasamy R, Devi M, Balasubramanian R, Ravi TK, et al. Prevalence of adverse drug reactions at a private tertiary care hospital in south India. J Res Med Sci. 2011;16(1):16-25.

Prajapati K, Desai M, Shah S, Panchal J, Kapadia J, Dikshit R. An analysis of serious adverse drug reactions at a tertiary care teaching hospital. Perspect Clin Res. 2016;7(4):181-6.

WHO. 4. What is Pharmacovigilance?, 2019. Available at: https://www.who.int/medicines/areas/. Accessed on 3 June 2019.

Upadhyaya HB, Vora MB, Nagar JG, Patel PB. Knowledge, attitude and practices toward pharmacovigilance and adverse drug reactions in postgraduate students of Tertiary Care Hospital in Gujarat. J Pharma Tech Res. 2015;6(1):29-34.

Saurabh MK, Karnani RK. An evaluation of knowledge, attitude and perception about adverse drug reactions and pharmacovigilance among intern doctors at a teaching hospital of Rajasthan. Natl J Physiol Pharm Pharmacol. 2016;6:111-5.

Coleman JJ, Pontefract SK. Adverse drug reactions. Clin Med. 2016;16(5):481-5.

Gupta R, Sharma D, Malhotra P. Assessment of knowledge, attitude and practice of pharmacovigilance among the undergraduate medical students in a northern Indian tertiary care teaching hospital: an observational study. Int J Pharm Sci Res. 2017;8(6):2654-59.

Desai CK, Iyer G, Panchal J, Shah S, Dikshit RK. An evaluation of knowledge, attitude, and practice of adverse drug reaction reporting among prescribers at a tertiary care hospital. Perspect Clin Res. 2011;2:129-36.

Chatterjee S, Lyle N, Ghosh S. A survey of the knowledge, attitude and practice of adverse drug reaction reporting by clinicians in eastern India. Drug Saf. 2006;29:641-2.

Thakuria N, Deka D, Choudhury D, Ahmed N. A cross sectional study to evaluate the knowledge, attitude and practices of healthcare professionals on pharmacovigilance at Silchar medical college and hospital, Assam, India. Int J Basic Clin Pharmacol. 2016;5:1481-9.

Korde RA, Radhika MS. A KAP study of pharmacovigilance among junior residents and interns of a tertiary care hospital. Int J Basic Clin Pharmacol. 2018;7(11):2178-83.

Gupta P, Udupa A. Adverse Drug Reaction Reporting and Pharmacovigilance: Knowledge, Attitudes and Perceptions amongst Resident Doctors. J Pharm Sci Res. 2011;3(2):1064-9.

Agarwal M, Ahmed J, Roy V. Knowledge, Attitude, and Practice About Pharmacovigilance Among Healthcare Providers of a Tertiary Care Teaching Hospital in New Delhi (India). MAMC J Med Sci. 2017;3:146-51.

Tandon V, Mahajan V, Khajuria V, Gillani Z. Under-reporting of adverse drug reactions: A challenge for pharmacovigilance in India. Ind J Pharmacol. 2015;47(1):65-71.

Kalaiselvan V, Prasad T, Bisht A, Singh S, Singh G. Adverse drug reactions reporting culture in Pharmacovigilance programme of India. Ind J Med Res. 2014;140(4):563-4.

Pimpalkhute SA, Jaiswal KM, Sontakke SD, Bajait CS, Gaikwad A. Evaluation of awareness about pharmacovigilance and adverse drug reaction monitoring in resident doctors of a tertiary care teaching hospital. Indian J Med Sci. 2012;66:55-61.

Modi PK, Kohli SK, Advani U, Singh H. Evaluation of knowledge, attitude and practice of pharmacovigilance among health care professionals in tertiary care teaching medical college in North India. World J Pharma Res. 2014;3:2691-7.

Prakasam A, Nidamanuri A, Kumar S. Knowledge, perception and practice of pharmacovigilance among community pharmacists in South India. Pharm Pract. 2012;10:222-6.