DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20211646

Coronary artery disease prescribing pattern and risk factor assessment in the patients undergoing angioplasty

Nilay D. Solanki, Nisha Patel, Shubha Desai, Varsha Patel

Abstract


Background: Coronary artery disease is caused by an obstruction in vascular supply to the heart. Angioplasty is a frequently used intervention for the management of CAD patients. Supportive and preventive therapies are additionally provided to these patients. Objective of current study was to assess the associated risk factors as well as prescribing trends in CAD patients.

Methods: A prospective study was conducted in 88 patients undergoing coronary angioplasty. Patients were assessed for risk factors of CAD. Medication history of patients was recorded in case record form for analysis of prescribing trend and its rationality. Data were statistically analyzed using prism software.

Results: In present study most of the CAD patients were male (80.68%) and mean age of patient was 59.19 years. Majority of patients (39.77%) were in age range of 61-70 years. Most common associated conditions at admission were hypertension and diabetes. In this study, BMI, stress, lack of exercise, hypertension, diabetes, family history of CVD were risk factors of CAD and significant correlation observed with risk factors and coronary artery disease. (p<0.05) Frequently prescribed drugs were antiplatelet, antibiotics, antihypertensive, antiulcer, antihyperlipidemic, antidiabetic agents. In 19.31% cases, drug interaction was detected out of which two cases recorded severe. Medical stents coated with everolimus, sirolimus were also prescribed.

Conclusions: It was concluded that history of cardiovascular disease, hypertension, diabetes are major risk factors of CAD. Certain level of irrationality in the prescribing trend was observed. Proper patient counselling and care can help in preventing CAD and reduces health burden.


Keywords


Coronary artery disease, Angioplasty, Antiplatelet drugs, Stents, Risk factors

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References


Lopez AD, Murray CC. The global burden of disease, 1990 2020. Nat Med 1998;4:1241 3.

Dawalji S, Venkateshwarlu K, Thota S, Venisetty PK, Venisetty RK. Prescribing pattern in coronary artery disease: a prospective study. Int J Pharm Res Rev. 2014;3(3):24-33.

Tasneem S, Fouzia N. Drug utilization study in ischemic heart diseases associated with diabetes and hypertension. Int J Pharma and Bio Sci. 2010;1(3):1-4.

Maas AH, Appelman YE. Gender differences in coronary heart disease. Neth Heart J. 2010;18(12): 598-603.

Biradar S, Nayakawadi N, PathiIndu, Rao M, Warad V. Prescribing pattern, drug utilization and clinical pharmacy services in acute coronary syndrome patients: Am J Drug Dis Dev. 2017;7(2):63-9.

Sekhri T, Kanwar RS, Wilfred R, Chugh P, Chhillar M, Aggarwal R, et al. Prevalence of risk factors for coronary artery disease in an urban Indian population. BMJ open. 2014;4(12):e005346.

Koria B, Kumar R, Nayak A, Kedia G. Prevalence of diabetes mellitus in urban population of ahmadabad city, Gujarat. Natl J Community Med. 2013;4(3):398-401.

Bastenie PA, Vanhaelst L, Neve P. Coronary-artery disease in hypothyroidism: observations in preclinical myxoedema. Lancet. 1967;290(7528):1221-2.

Grines CL, Cox DA, Stone GW, Garcia E, Mattos LA, Giambartolomei A, et al. Coronary angioplasty with or without stent implantation for acute myocardial infarction. New Eng J Med. 1999;341 (26):1949-56.

Chisari A, Pistritto A, Piccolo R, La Manna A, Danzi G. The ultimaster biodegradable-polymer sirolimus-eluting stent: an updated review of clinical evidence. Int J Mol Sci. 2016;17(9):1490.

Ghosh A, Das AK, Pramanik S, Saha UK. Drug utilization study in patients of acute coronary syndrome on follow-up visits at a tertiary care centre In Kolkata. Asian J Pharma Life Sci. 2012;2231:4423.

Thomas BR, Catherin TJ, Sabu N, Lekshmi ES, Baby N, Menaka K, et al. Prescribing Pattern of Cardiovascular Drugs-A Prospective Observational Study. Indian J Practice. 2017;10(4):287.

Naveen A, Sravani MR, Venkat JN. Drug utilization patterns in acute coronary syndrome at a tertiary care teaching hospital: A retrospective, non interventional and observational study. Pharma Innov. 2017;6(9, part H):538.

Steptoe A, Kivimäki M. Stress and cardiovascular disease. Nat Rev Cardiol. 2012;9(6):360.

Dimsdale JE. Psychological stress and cardiovascular disease. J Am Coll Cardiol. 2008;51(13):1237-46.

Castelli WP. Epidemiology of coronary heart disease: the Framingham study. Am J Med. 1984;76(2):4-12.

Ranthe MF, Petersen JA, Bundgaard H, Wohlfahrt J, Melbye M, Boyd HA. A detailed family history of myocardial infarction and risk of myocardial infarction–a nationwide cohort study. PloS one. 2015; 10(5):e0125896.

Acharya KG, Shah KN, Solanki ND, Rana DA. Evaluation of antidiabetic prescriptions, cost and adherence to treatment guidelines: A prospective, cross-sectional study at a tertiary care teaching hospital. J Basic Clin Pharma. 2013;4:82-7.

Solanki N, Patel Y. Drug utilization pattern and drug interaction study of antibiotics prescribed to orthopedic patients in private hospital. Arch Pharma Pract. 2019;10(4):114-8.

Solanki N, Patel V, Patel R. Prescribing trends in cardiovascular conditions: a prospective cross-sectional study. J Basic Clin Pharma. 2019;10:23-6.

Solanki ND, Patel P. Drug utilization pattern and pharmacoeconomic analysis of antihypertensive drugs prescribed in secondary care hospital in Gujarat, India. Asian J Pharm Clin Res. 2017;10(3):120-4.