Ceftraixone induced anaphylaxis and death: a case report

Authors

  • Ameya Puranik Department of Pharmacology, JNMC, Sawangi, Wardha, Maharashtra, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20211030

Keywords:

Ceftriaxone, Anaphylaxis, Death, Drug safety, Pharmacovigilance, ADR, SUSAR

Abstract

Ceftriaxone, a broad spectrum third generation cephalosporin antibiotic and sulbactam is a beta-lactamase inhibitor. The combination is used for pre-operative surgical prophylaxis for prevention is secondary bacterial infection.  We describe a patient who developed anaphylaxis and death soon after intravenous administration of ceftriaxone and sulbactam combination and review similar cases of adverse effects to these class of drugs. The patient was a 68 year old male admitted to surgery ward for obstructed inguinal hernia. He was prescribed injection ceftriaxone and sulbactam combination along with concomitant medication injection pantoprazole and injection metronidazole. The patient was injected injection ceftriaxone and sulbactam, within 15 minutes he suddenly developed anaphylactic shock and died for fluid aspiration in lungs during resuscitation. PubMed was searched for the following terms: anaphylaxis, ceftriaxone, sulbactam. The papers containing these terms and their references were reviewed. Anaphylactic shock caused by ceftriaxone is an uncommon adverse event in patients receiving the drug. However, similar reactions have been observed in some cases in India and world-wide. Clinicians should be aware that anaphylaxis secondary to ceftriaxone and sulbactam combination is a serious death threatening side-effect.

Author Biography

Ameya Puranik, Department of Pharmacology, JNMC, Sawangi, Wardha, Maharashtra, India

Junior Resident

References

Tripathi KD. Essentials of Medical Pharmacology. 7th ed. Jaypee. 2013;727.

Chalkiadakis GE, Gonnianakis C, Tsatsakis A, Tsakalof A, Michalodimitrakis M. Preincisional single-dose ceftriaxone for the prophylaxis of surgical wound infection. Am J Surg. 1995;170(4):353-5.

Sader H. Historical overview of the cephalosporin spectrum: Four generations of structural evolution. Antimicrobic Newsletter. 1992;8(12):75-82.

Centers for Disease Control and Prevention (CDC). Update to CDC's Sexually transmitted diseases treatment guidelines, 2010: oral cephalosporins no longer a recommended treatment for gonococcal infections. Morb Mortal Wkly Rep. 2012;61(31):590-4.

Kelkar PS, Li JT. Cephalosporin allergy. N Engl J Med. 2001;345(11):804-9.

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Published

2021-03-22

How to Cite

Puranik, A. (2021). Ceftraixone induced anaphylaxis and death: a case report. International Journal of Basic & Clinical Pharmacology, 10(4), 442–443. https://doi.org/10.18203/2319-2003.ijbcp20211030

Issue

Section

Case Reports