Antifertility effect of curcumin, an indigenous medicine in rats

Authors

  • R. N. Maiti Department of Pharmacology, Midnapore Medical College, Midnapore, West Bengal, India
  • U. K. Roy Department of Anaesthesiology, Murshidabad Medical College, Midnapore, West Bengal,
  • Subhayan Das Department of Pharmacology, Midnapore Medical College, Midnapore, West Bengal, India
  • A. K. Das Department of Pharmacology, R. G. Kar Medical College, West Bengal, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20210185

Keywords:

Curcuma longa linn, Antifertility effect, Indigenous medicine

Abstract

Background: Curcumin is an active constituent, obtained from rhizome of Curcuma longa linn, known to have broad medicinal properties, was studied for its effect on fertility in female rats. Curcumin has anti-ovulatory effect probably by its antiestrogenic activity through suppression of negative feedback of estrogen on pituitary.

Methods: Inbred Charles Foster female albino rats (150-180 gm) were used for study. They were divided into different groups and treated with curcumin (25 mg/kg. and 50 mg/kg body weight) as per schedule. The antigonadotropic, antiestrogenic, anti-implantation and abortifacient effect on curcumin treated albino rats were demonstrated.

Results: The results showed significant reduction in the number of implants and size of litters in curcumin treated rats compared to normal control group. The results were compared with Tamoxifen (10mg/ kg bodyweight) a known antifertility drug, which further substantiated the antifertility effects of curcumin.

Conclusions: The results indicated the ways in which curcumin exerts antifertility effects and thus can play a vital role in fertility control.

Author Biographies

R. N. Maiti, Department of Pharmacology, Midnapore Medical College, Midnapore, West Bengal, India

Professor and H.O.D, Department of Pharmacology, Midnapore Medical College and Hospital

U. K. Roy, Department of Anaesthesiology, Murshidabad Medical College, Midnapore, West Bengal,

Assistant Professor, Department of Anesthesiology and critical care, Murshidabad Medical College and Hospital

Subhayan Das, Department of Pharmacology, Midnapore Medical College, Midnapore, West Bengal, India

Postgraduate trainee, Department of Pharmacology, Midnapore Medical College and Hospital.

A. K. Das, Department of Pharmacology, R. G. Kar Medical College, West Bengal, India

Professor,Department of Pharmacology, R.G Kar Medical College and Hospital, West Bengal.

References

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Published

2021-01-25

How to Cite

Maiti, R. N., Roy, U. K., Das, S., & Das, A. K. (2021). Antifertility effect of curcumin, an indigenous medicine in rats. International Journal of Basic & Clinical Pharmacology, 10(2), 167–171. https://doi.org/10.18203/2319-2003.ijbcp20210185

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Section

Original Research Articles