Efficacy and tolerability of vitamin C as an add on therapy to standard antihypertensive regimen

Vivek Singh, Ujjwal Sourav


Background: In both developing and developed countries, elevated arterial blood pressure is perhaps the most significant public health issue. It is widespread, often asymptomatic, readily observable, typically easily treatable and, if left untreated, frequently leads to lethal complications. According to the Framingham report, the prevalence of hypertension in the white suburban population is almost one-fifth of those with blood pressure >160/95 mm Hg, while almost half of those with blood pressure >140/90 mm Hg. Aim and objectives were to estimate the efficacy of vitamin C as an add-on therapy to the antihypertensive regimen.

Methods: The prospective comparative study was undertaken in mild to moderate hypertensive patients to find out the efficacy and tolerability of vitamin C as an add-on therapy to the standard anti-hypertensive regimen in the reduction of blood pressure and C-reactive protein levels. This study was done at the Saraswathi institute of medical sciences, Hapur, UP.

Results: For Systolic BP as well as DBP, at baseline there was non-significant difference among all the four group with p value 0.28, whereas at all the visit at 1, 3 and 6 month there was significant difference among the four group with p value<0.01, <0.001 and<0.001.

Conclusions: There was significant addon benefit of vit C when added with standard antihypertensive regimen.


Adenomysis, Abnormal uterin bleeding, MR hysterography

Full Text:



Harrison, Naomi DL, Fischer, Gordon H. Williams. Hypertensive vascular disease. In Dennis L Kasper, Editor. Principles of Internal Medicine, 16th Edition, US: Mc Graw Hill. 2005;2:1463-81.

Kearney PM, Whelton M, Reynolds K, Whelton PK, He J. Worldwide prevalence of hypertension: a systematic review. J Hypertens. 2004;22(1):11-9.

Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo Jr JL, et al. Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension. 2003;42(6):1206-52.

Ezzati M, Lopez AD, Rodgers A. Selected major risk factors and global and regional burden and complications of hypertension. Lancet. 2002;360:1347-60.

Stephen J. McPhee, Barry M. Massie, Systemic hypertension, Current medical diagnosis and treatment 2006, 45th Edition, McGraw Hill, Chapter 11. 419-45

Chae CU, Lee RT, Rifai N, Ridker PM. Blood pressure and inflammation in apparently healthy men. Hypertension 2001;38:399-403.

Stumpf C, John S, Jukic J, Yilmaz A, Raaz D, Schmieder RE, et al. Enhanced levels of platelet P-selectin and circulating cytokines in young patients with mild arterial hypertension. J Hypertens. 2005;23(5):995-1000.

Schillaci G, Pirro M, Gemelli F. Increased C-reactive protein concentrations in hypertension: the role of systolic and pulse pressures. J Hypertens. 2003;21:1841-6.

Engstrom G, Lind P, Hedblad B, Stavenow L, Janzon L, Lindgarde F. Long-term effects of inflammation-sensitive plasma proteins and systolic blood pressure on incidence of stroke. Stroke. 2002;33:2744-9.

Taddei S, Virdis A, Ghiadoni L, Magagna A, Salvetti A, Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in hypertension, Circulation. 1998;97(22):2222-9.

Duffy SJ, Gokce N, Holbrook M, Huang A, Frei B, Keaney JF Jr, et al. Treatment of hypertension with ascorbic acid. Lancet. 1999;354:2048-9.

Block G, Mangel AR, Norkus EP, Patterson BH, Levander OA, Taylor PR. Ascorbic acid status and subsequent diastolic and systolic blood pressure. Hypertension. 2001;37:261-7.

Mullan BA, Young IS, Fee H, McCance DR. Ascorbic acid reduces blood pressure and arterial stiffness in type 2 diabetes. Hypertension. 2002;40:804-9.

Block G, Jensen C, Dietrich M, Norkus EP, Hudes M, Packer L. Plasma C-reactive protein concentrations in active and passive smokers: influence of antioxidant supplementation. J Am Col Nutrit. 2004;23(2):141-7.