DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20205023

Screening of anticonvulsant effect of carvedilol on electrically induced convulsions in Wistar albino rats

Biacin Babu, Madhavrao Chavan

Abstract


Background: Epilepsy is one of the major central nervous system disorders. The parent study aimed to screen the anticonvulsant effect of carvedilol on electrically induced convulsions in Wistar albino rats.

Methods: This study was done in Wistar albino rats. A total of 30 rats were divided into 6 groups each of six rats. group-I (0.9% normal saline), group-II diphenylhydantoin (10 mg/kg/BW/ip), group-III carvedilol (1mg/kg/BW/PO), group-IV carvedilol (2 mg/kg/BW/PO) and group-V carvedilol (4 mg/kg/BW/PO). All the groups were administered drugs and subjected to electric shock. Scores of seizures and percentage of protection were recorded to compare between the groups. One was ANOVA (post hoc) followed by Dunnet t test applied to find the statistically significant between the groups.

Results: Group-I showed significant difference compared to other groups. Group-II showed significant difference with group-III and IV not with V. High dose of test drug and standard drug showed similar results in percentage of seizures prevention. Control and low doses of test drugs showed significant difference compared to standard and high dose of test drug in seizures prevention.

Conclusions: High of carvedilol showed significant seizures prevention compared to low doses and control group.


Keywords


Albino rats, Carvedilol, Convulsions, Diphenylhydantoin, Epilepsy, Maximal electroshock seizure

Full Text:

PDF

References


Lowenstein DH. Seizures and epilepsy. In: Fauci AS, Braunwald E, Kasper DL, Hauser SL, LongoDL, Jameson JL et al editors. Harrison’s principles of internal medicine vol II. 17th edition. New York:McGraw-Hill. 2008: 2498-2512.

McNamara JO. Pharmacotherapy of the epilepsies. In: Laurence LB, John SL, Keith LP editors. Goodman and Gilman’s Pharmacological Basis of Therapeutics. 12th edition. New Delhi: McGraw-Hill. 2011;583-607.

Tripathi KD. Essentials of medical pharmacology. 7th edition. New Delhi: Jaypee brothersmedical publishers. 2013;512-38.

Vogel HG. Drug discovery and evaluation: Pharmacological assays. 3rd edition. Berlin: Springer. 2008: 662-709.

Jalapure SS, Salahuddin M, Imtiyaz SM, Manvi FV. Anticonvulsant effects of Calotropis procera root in rats. Pharmaceutical Biology. 2009;47(2):162-7.

Medhi B, Prakash A. Practical Manual of Experimental and Clinical Pharmacology. 1st edition. Jaypee brothers. 2010: 186-204.

Thomas CW, David PW. Adrenergic Agonists and Antagonists. In: Laurence LB, John SL, Keith LP editors. Goodman and Gilman’s Pharmacological Basis of Therapeutics. 12th edition. New Delhi: McGraw-Hill. 2011: 292-333.

Hudson SA, McAnaw J, Dreischulte T. Chronic heart failure. In: Walker R. Whittlesea C editors. Clinical Pharmacy and Therapeutics. 5th edition. London: Elsevier. 2012;333-53.

Shaughnessy KMO. Adrenergic mechanisms and drugs. In: Bennett PN, Brown MJ, Sharma P editors. Clinical Pharmacology. 11th edition. London: Elsevier. 2012;382-427.

Liu S. Adrenergic agents. In: Beagle JM, Block JH. Wilson and Gisvold’s Organic Medicinal and pharmaceutical chemistry. 12th ed. New Delhi: Lippincott Williams and Wilkins. 2011;519-54.

Gupta SK. Drug screening methods. 2nd edition. Jaypee brothers. 2009;400-22.

Louis J, Papanicaulao J, Summers RJ. Role of central adrenoceptors in control of PTZ induced seizures in rats. Br J Pharmac. 1982;75:441-6.

Kajiwara K, Yanagita T, Nakashima Y, Wada A. Differential effects of short and rolonged exposure to carvedilol on voltage dependant Na+ channels in cultured bovine adrenal medullary cells. J Pharmacol Exp Ther. 2002;302:211-8.

Frantseva MV, Velazquez PJL, Tsoraklidis G, Mendonca AJ, Adamchik Y, Burnham MW et al. Oxidative stress is involved in seizure-induced neurodegeneration in the kindling model of epilepsy. Neurosci. 2000;97:431-5.

Medhi B, Prakash A. Practical Manual of Experimental and Clinical Pharmacology. 1st edition. Jaypee brothers. 2010;186-204.

Walker MC, Surges R, Fisher A. Mechanism of antiepileptic drug action. In: Simon S, Emilio P, Engel JJ editors. The treatment of epilepsy. 3rd edition. Singapore: Wiley Blackwell; 2009: 94-95.