Sulfadiazine induced Stevens Johnson syndrome in toxoplasmosis patient: a case report

Authors

  • Sagar Raju Department of Pharmacy Practice, Mandya Institute of Medical Science, Mandya, Karnataka, India
  • Shilpa Shashidharan Department of Pharmacy Practice, Mandya Institute of Medical Science, Mandya, Karnataka, India
  • Rani M. Kurian Department of Pharmacy Practice, Mandya Institute of Medical Science, Mandya, Karnataka, India
  • Rima Ramla Department of Pharmacy Practice, Mandya Institute of Medical Science, Mandya, Karnataka, India
  • Arun Paingamkulangara Department of Pharmacy Practice, Mandya Institute of Medical Science, Mandya, Karnataka, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20204108

Keywords:

Stevens johnson syndrome is an acute, self-limited disease, presenting as severe mucosal erosions with widespread erythematous, cutaneous macules or atypical targets. Even though sulfadiazine has been mainly associated with haematological-related adverse

Abstract

Stevens johnson syndrome is an acute, self-limited disease, presenting as severe mucosal erosions with widespread erythematous, cutaneous macules or atypical targets. Even though sulfadiazine has been mainly associated with haematological-related adverse effects, sulfadiazine induced skin necrosis has received less attention or went unrecognized. Here is a 29-year- old Indian male received T. Sulfadiazine 500mg 1-1-1-1 and experienced a severe skin reaction which was diagnosed as stevens johnson syndrome (SJS). The above drug will be implicated in cases of stevens johnson syndrome (SJS)/toxic epidermal necrosis (TEN). There are few case reports of that have been associated with stevens johnson syndrome (SJS)/toxic epidermal necrosis (TEN). We hope that this case report creates awareness to the health care professionals. Clinicians must be aware of these adverse reactions and advise their patients to contact them as soon as they observe any unexpected clinical response. Early diagnosis helps the clinician to elude secondary infection and subsequent complications. The offending drug should be discontinued and never be rechallenged.

 

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Published

2020-09-22

How to Cite

Raju, S., Shashidharan, S., Kurian, R. M., Ramla, R., & Paingamkulangara, A. (2020). Sulfadiazine induced Stevens Johnson syndrome in toxoplasmosis patient: a case report. International Journal of Basic & Clinical Pharmacology, 9(10), 1615–1617. https://doi.org/10.18203/2319-2003.ijbcp20204108

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Section

Case Reports