Role of therapeutic drug monitoring of azathioprine and thiopurine methyltransferase enzyme status in patients with inflammatory bowel disease: Indian scenario

Authors

  • Maninder Singh Department of Pharmacology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India
  • Sandeep Kaushal 1Department of Pharmacology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India
  • Kanchan Gupta Department of Pharmacology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India
  • Ajit Sood Department of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20204109

Keywords:

Inflammatory bowel disease, Ulcerative colitis, Chron’s disease, Therapeutic drug monitoring, Azathioprine, 6-Methylmercaptopurine, 6-Thioguanine nucleotides

Abstract

Inflammatory bowel disease is mainly caused by dysragulated immune system. Inflammatory bowel disease incidences are rising in Asian countries with difficulty in their diagnosis and managements. There is rising the incidences and prevalence rate in India. Inflammatory bowel disease has two major subtypes Ulcerative colitis and chron’s disease. In ulcerative colitis inflammation occurs in lower part of large intestine that extend from anal verge to proximal colon while in case of chron’s disease there is transmural inflammation of gastrointestinal tract. This review is to provide comprehensive review focused on the current status of therapeutic drug monitoring of azathioprine metabolites in patients of inflammatory bowel disease.

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Published

2020-09-22

How to Cite

Singh, M., Kaushal, S., Gupta, K., & Sood, A. (2020). Role of therapeutic drug monitoring of azathioprine and thiopurine methyltransferase enzyme status in patients with inflammatory bowel disease: Indian scenario. International Journal of Basic & Clinical Pharmacology, 9(10), 1618–1624. https://doi.org/10.18203/2319-2003.ijbcp20204109

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Section

Review Articles