DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20204107

Adrenal crisis: a rare endocrine emergency with challenging diagnosis

Ankit Bhardwaj, Vivek Singh, Kaveri Kapoor, Anil Kem

Abstract


Adrenal crisis is a rare life-threatening medical endocrine emergency with non-specific insidious symptoms and challenging diagnosis. An appropriate timely diagnosis and treatment can save life. Although most doctors are educated by “sick day rules,” but are reluctant to start glucocorticoids, increase doses or switch to parental injections. Our case report highlights various aspect of adrenal crisis.


Keywords


Adrenal crisis, Endocrine emergency, Glucocorticoids

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References


Addison T. On the constitutional and local effects of disease of the supura-renal capsules. Highley, London; 1855.

Hahner S. Acute adrenal crisis and mortality in adrenal insufficiency: still a concern in 2018! In Annales d'endocrinologie. Elsev Mass. 2018;79(3):164-6.

Higham CE, Olsson-Brown A, Carroll P, Cooksley T, Larkin J, Lorigan P, et al. Society for Endocrinology Clinical Committee. Society for endocrinology endocrine emergency guidance: Acute management of the endocrine complications of checkpoint inhibitor therapy. Endocr Connect. 2018;(7):G1-7.

Betterle C, Presotto F, Furmaniak J. Epidemiology, pathogenesis, and diagnosis of Addison's disease in adults. J Endocrinol Invest. 2019;42(12):1407-33.

Husebye ES, Allolio B, Arlt W, Badenhoop K, Bensing S, Betterle C, et al. Consensus statement on the diagnosis, treatment and follow-up of patients with primary adrenal insufficiency. J Intern Med. 2014;275(2):104-15.

Elsevier Point of Care. Primary adrenal insufficiency, clinical overview. Available at: https://www.clini calkey.com/#!/content/67-s2.0-74c5f862-11e4-4bfd-abe8-8409af9fe071. Accessed on 27 July 2020.

Charmandari E, Nicolaides NC, Chrousos GP. Adrenal insufficiency. Lanc. 2014;383(9935): 2152-67.

Amrein K, Martucci G, Hahner S. Understanding adrenal crisis. Intensive Care Med. 2018;44:652-5.

Brunton LL, Hilal R, Knollmann BC. Goodman & Gilman's the pharmacological basis of therapeutics. 13th edition. 2018; 130-40.

Nieman LK, Lacroix A, Martin K. Clinical manifestations of adrenal insufficiency in adults. Retrieved March. 2018. Available at: https://www.uptodate.com/contents/clinical-manifestations-of-adrenal-insufficiency-in-adults. Accessed on 14th July 2020.

Walsh J, Gittoes N, Selby P. Society for Endocrinology Clinical Committee. Society for Endocrinology Endocrine Emergency Guidance: emergency management of acute hypercalcaemia in adult patients. Endocr Connect. 2016;5:G9-11.