DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20204084

Analgesic, anti-inflammatory and antipyretic activities of ethanol extract of Annona senegalensis leaves in experimental animal models

Anthony U. Megwas, Godwin C. Akuodor, Leo C. Chukwu, Daniel O. Aja, Edmund M. Okorie, Elochukwu C. Ogbuagu, Desmond O. Eke, Anuli N. Chukwumobi

Abstract


Background: This study was carried out to establish the analgesic, anti-inflammatory and antipyretic effects of the ethanol extract of Anonna senegalensis leaves in experimental animals.

Methods: The analgesic activity was measured using the abdominal constriction and tail flick tests. The anti-inflammatory activity was performed using xylene and egg-albumen paw induced tests, while the antipyretic activity was measured using brewer’s yeast and 2, 4 dinitrophenol induced pyrexia tests, respectively.

Results: The leaf extract at all doses used exhibited significant (p<0.05) analgesic, anti-inflammatory and antipyretic activities.

Conclusions: Results show that ethanol leaf extract of Anonna senegalensis possess therapeutic potential against pains and feverish conditions, supporting the claims of its this plant as remedy for similar ailments.


Keywords


Anonna senegalensis, Analgesic, Anti-inflammatory, Antipyretic

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References


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