DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20202566

Herbal extraction procedures: need of the hour

Nandhini Saravanabavan, Kartik J. Salwe, R. Sudar Codi, Manimekalai Kumarappan

Abstract


Extraction is the first most important step for preparing herbal drug formulations. It serves as an alternate method to identify the lead compound by isolating the active compounds from the crude drug using various extraction techniques by adding suitable solvent. Selection of solvent is the most important step as the success rate depends on it. Thus, by identifying the lead compound, extraction plays an important role in the process of drug discovery. In this review, different methods of extraction used for extracting the herbal extracts have been discussed with their advantages and disadvantages and also a brief discussion on solvent selection and actions of few phytochemicals have also been discussed.


Keywords


Herbal extraction, Soxhlation, Percolation, Percolation, Sonication

Full Text:

PDF

References


Oancea S, Grosu C, Coman D, Stoia M. Conventional and non-conventional extraction of anthocyanins from Rubus idaeus L grown in Romania. Advances in Environmental technologies, Agriculture, Food and Animal Sciences; 2013: 247-251.

Selvamuthukumaran M, Shi J. Recent advances in extraction of antioxidants from plant by-products processing industries. Food Quality Safety. 2017;1(1):61-81.

Kothari V, Gupta A, Naraniwal M. Comparative study of various methods for extraction of antioxidant and antibacterial compounds from plant seeds. J Natural Remedies. 2012;12(2):162-73.

Azwanida NN. A review on the extraction methods use in medicinal plants, principle, strength and limitation. Med Aroma Plants. 2015;4:2-6.

Tartian AC, Cotea VV, Niculaua M, Zamfir CL, Colibaba CL, Morasanu AM. The influence of different techniques of maceration on the aromatic and phenolic profile of the aromatic and phenolic profile of the Busuioaca de Bohotin wine. Bio web Conferences; 2017: 9.

Rivero FJ. Impact of post fermentative maceration with overripe seeds on the color stability of red wines. Food Chem. 2019;272:329-36.

Zhang QW, Lin LG, Ye WC. Techniques for extraction and isolation of natural products: a comprehensive review. Chinese Med. 2018;13:20.

Fuleky G, Czinkota I. Hot water percolation (HWP): A new rapid soil extraction method. Plant Soil. 1993;157:131-5.

Kalia VC, Lal S, Rashmi. Modified cold percolation method for extracting oil from oil seeds. J Scientific Industrial Res. 2002;61(8):630-4.

Cowan MM. Plant products as anti-microbial agents. Clinical Microbiology Reviews. 1999;12(4):564-82.

Adouni K, Mekhelfi T, Daouadji MZD, Achour L. Decoction, Infusion and ethanolic extract of Juncus acutus Rhizome: Phytochemical content and Antioxidant properties. Int J Pharm Sci Res. 2018;48(1):148-52.

Singh J. Maceration, percolation and infusion techniques for the extraction of medicinal and aromatic plants. Extraction technologies for medicinal and aromatic plants; International centre for science and high technology, Trieste, Italy; 2008.

Nagalingam A. Drug delivery aspects of Herbal medicines. Japanese Kampo Medicines for the treatment of common diseases. Focus on Inflammation; 2017: 143-64.

Komarek M, Chrastny V, Ettler V, Tlustos P. Evaluation of extraction/digestion techniques used to determine lead isotopic composition in forest soils. Analytical Bioanalytical Chemistry. 2006;385(6):1109-15.

Castro MDL, Ayuextso GLE. Soxhlet extraction of solid materials: an outdated technique with a promising innovative future. Analytical Chimica Acta. 1998;369(1-2):1-10.

Redfern J, Kinninmonth M, Verran J. Using Soxhlet Ethanol Extraction to produce and test plant material (Essential Oils) for their antimicrobial properties. J Microbial Biol Educ. 2014;15(1):45-6.

Delazar A, Nahar L, Hamedeyszdan S, Sarker SD. Microwave assisted extraction in natural products isolation. Methods Mol Biol. 2012;864:89-115.

Tatke P, Jaiswal Y. An overview of Microwave assisted extraction and its applications in herbal drug research. Res J Med Plants. 2011;5(1):21-31.

Gupta A, Naraniwal M, Kothari V. Modern extraction methods for preparation of bioactive plant extracts. Int J Applied Natural Sci. 2012;1(1):8-19.

Altemimi A, Watson DG, Choudhary R, Dasari MR, Lightfoot DA. Ultrasound assisted extraction of phenolic compounds from peaches and pumpkins. PLOS ONE. 2016;11(2).

Torres NM, Ayora T, Andrews HE, Sanchez A. Ultrasound assisted extraction for the recovery of phenolic compounds from vegetable sources. Agronomy. 2017;7:1-19.

Esclapez MD, Garcia PJV, Mulet A, Carcel JA. Ultrasound extraction of natural products. Food Eng Rev. 2011;3(2).

Sapkale GN, Patil SM, Surwase US, Bhatbhage PK. Supercritical fluid extraction: a review. Int J Chem Sci. 2010;8:729-43.

Bhusnure OG. Importance of supercritical fluid extraction techniques in pharmaceutical industry: a review. Indo-American J Pharmaceutical Res. 2015;5(12):3785-99.

Wrona O, Rafinska K, Mozenski C, Buszewski B. Supercritical fluid extraction of bioactive compounds from plant materials. J AOAC Int. 2017;100(6):1624-35.

Ayre A. Supercritical fluid extraction: a green paradigm in the area of separation science. Asian J Biomedical Pharmaceutical Sci. 2013;3(23):1-7.

Das K, Tiawari RKS, Shrivastava DK. Techniques for evaluation of medicinal plant products as antimicrobial agent: Current methods and future trends. J Med Plants Res. 2010;4(2):104-11.

Wng GX. In vivo anti-helmintic activity of five alkaloids from Macleaya microcarpa (Maxim) Fedde against Dactylogyrusintermedius in Carrasius auratus. Veterinary Parasitol. 2010;171:305-13.

Ncube NS, Afolayan AJ, Okoh AI. Assessment techniques of antimicrobial properties of natural compounds of plant origin: current methods and future trends. African J Biotechnol. 2008;7(12):1797-806.

Hussain G. Role of plant derived alkaloids and their mechanism in Neurodegenerative disorders. Int J Biol Sci. 2018;14(3):341-57.

Evans RC, Miller N, Paganga G. Anti-oxidant properties of phenolic compounds. Trends in plant Science. 1997;2(4):152-9.

Panche NA, Diwan DA, Chandra RS. Flavanoids: an overview. J Nutritional Sci. 2016;5(47):1-15.

Man S, Gao W, Zahang Y, Huang L, Liu C. chemical study and medical application of saponins as anticancer agents. Fitoterapia. 2018;81(7):703-14.

Ashok KP, Upadhyaya K. Tannins are Astringent. J Pharmacognosy Phytochemistry. 2012:1(3):45-50.

Rohini K, Srikumar PS. Theraapeutic role of Coumarins and Coumarin related compunds. J Thermodyn Catal. 2014;5(2):1-3.

Cowan MM. Plant products as anti-microbial agents. Clinical Microbiology Reviews. 1999;12(4):564-82.

He K, Li X, Chen X. Evaluation of antidiabetic potential of selected traditional Chinese medicines in STZ induced diabetic mice. J Ethnopharmacol. 2011;137(3):1135-42.

Pojer E, Mattivi F, Johnson D, Stockley CS. The case for anthocyanin consumption to promote human health: a review. Compr Rev Food Sci Food Safety. 2013;12:483-508.

Gallily R, Yekhtin Z, Hanus OL. The anti-inflammatory properties of Terpenoids from Cannabis. Cannabis Cannabinoid Res. 2018;3(1):282-90.

Maniyar Y, Bhixavatimath P, Agashikar NV. Anti-diarrheal activity of flowers of Ixora Coccinea Linn in rats. J Ayurveda Integr Med. 2010;1:287-91.