DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20204105

Injection ranitidine induced death

S. Anandhi, R. Mani

Abstract


Ranitidine is a histamine-2-receptor antagonist. It was a commonly used drug. It holds excellent safety record. Anaphylactic reactions to ranitidine is uncommonly encountered. Death due to ranitidine is extremely a rare event and very few cases are reported world-wide. Clinical history, Lab investigations and histological data of a 43-Years old woman with negative history of allergic events, who died suddenly after the intra-venous administration of 50mg of intravenous ranitidine which was prescribed as a routine pre medication prior hysterectomy is presented below. Though the incidence of anaphylactic reactions is less with ranitidine, precautions to be taken prior administration of the drug and when such an event is encountered it should be promptly managed.


Keywords


Ranitidine, Anaphylaxis, Death, Safety

Full Text:

PDF

References


Oliva A, Partemi S, Arena V, De Giorgio F, Colecchi C, Fucci N et al. Fatal injection of ranitidine: a case report. J Med Case Rep. 2008;2:232.

Rethnam U, Yesupalan S. Anaphylactic reaction associated with Ranitidine in a patient with acute pancreatitis: a case report. J Med Case Reports. 2007;1(1):75.

U.S. Food and Drug. FDA Updates and Press Announcements on NDMA in Zantac (ranitidine). Available from: http://www.fda.gov/drugs/drug-safety-and-availability/fda-update Accessed on 4 March 2020.

Chopra D, Arora P, Khan S, Dwivedi S. Anaphylaxis following ins and press-announcements ndma zantac ranitidine intravenous ranitidine: A rare adverse reaction of a common drug. Indian J Pharmacol. 2014;46(2):234-36.

Demirkan K, Bozkurt B, Karakaya G, Kalyoncu F. Anaphylactic reaction to drugs commonly used for gastrointestinal system diseases: 3 case reports and review of the literature. J Investig Allergol Clin Immunol. 2006;16(3):203-9.