Analysis of antimicrobial susceptibility pattern of ocular infections at Regional Ophthalmic Institute in India

Authors

  • Qudsia Nuzhat Department of Pharmacology, Sri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh, India
  • Arkapal Bandyopadhyay Department of Pharmacology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
  • Rakesh Chandra Chaurasia Department of Pharmacology, Government Medical College, Azamgarh, Uttar Pradesh, India
  • Satya P. Singh Department of Ophthalmology, Moti Lal Nehru Medical College, Allahabad, Uttar Pradesh, India
  • Monica Singh Department of Microbiology, Moti Lal Nehru Medical College, Allahabad, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20201192

Keywords:

Antibiotics, Bacteria, Infections, Ocular, Resistance

Abstract

Background: Ocular infections are a result of alteration in the normal microbial flora of eye. They are not only responsible for increase in morbidity varying from self-limiting trivial infection to sight threatening infection but also blindness.

Methods: Patients with ocular infections were recruited at Regional Institute of Ophthalmology, Moti Lal Nehru Medical College, Allahabad, Uttar Pradesh. Bacterial profile in ocular infections and susceptibility pattern to commonly used antibiotics were analyzed amongst these patients. The isolated organism was then identified by colony morphology, gram stain and biochemical test following which in vitro susceptibility test was performed by Kirby-Bauer disc diffusion method and interpreted clinically.

Results: Staphylococcus aureus and coagulase negative Streptococcus were most common etiological agents of ocular infections in the present study.  It was observed that bacterial isolates were highly (in 100% of cases) susceptible to vancomycin and chloramphenicol among gram positive organisms. Gram negative organisms showed higher susceptibility to moxifloxacin, tobramycin and gentamycin. Pseudomonas was seen to have sensitivity towards ceftazidime and cefazolin.

Conclusions: The present study gives an insight into use of ocular antimicrobials in northern India. These findings illustrate the need for constant bacterial surveillance before starting empirical treatment.

Author Biographies

Qudsia Nuzhat, Department of Pharmacology, Sri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh, India

Department of pharmacology

Arkapal Bandyopadhyay, Department of Pharmacology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India

Department of pharmacology

Rakesh Chandra Chaurasia, Department of Pharmacology, Government Medical College, Azamgarh, Uttar Pradesh, India

Department of Pharmacology

Satya P. Singh, Department of Ophthalmology, Moti Lal Nehru Medical College, Allahabad, Uttar Pradesh, India

Department of Ophthalmology,

Monica Singh, Department of Microbiology, Moti Lal Nehru Medical College, Allahabad, Uttar Pradesh, India

Department of Microbiology

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Published

2020-03-24

How to Cite

Nuzhat, Q., Bandyopadhyay, A., Chaurasia, R. C., Singh, S. P., & Singh, M. (2020). Analysis of antimicrobial susceptibility pattern of ocular infections at Regional Ophthalmic Institute in India. International Journal of Basic & Clinical Pharmacology, 9(4), 642–646. https://doi.org/10.18203/2319-2003.ijbcp20201192

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Original Research Articles