Analysis of gastrointestinal drugs in patients admitted in CCU and ICCU of a tertiary care hospital in Goa, India

Authors

  • Shantadurga S. Kerkar Department of Pharmacology, Goa Medical College, Bambolim Goa, India
  • Padma N. Bhandare Department of Pharmacology, Goa Medical College, Bambolim Goa, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20191117

Keywords:

Critically-ill patients, Gastrointestinal ailments, Medicines, PPIs

Abstract

Background: Gastrointestinal (GI) diseases are a common problem worldwide. They are frequently encountered in non-critical as well as in critically ill hospitalized patients.

Methods: This was a prospective and observational study conducted on patients admitted in CCU and ICCU of Goa Medical College and Hospital. Data was collected from the patients’ case records and was analysed referring to WHO prescribing indicators. Data was represented as Mean±SD, number and frequency.

Results: A total of 2250 drugs were prescribed, out of which 376 (16.71%) were gastrointestinal drugs. Most common route of administration was oral 323 (85.90%). Prescription patterns of GI drugs were:  275 (73.14%) from National List of Essential Medicines, 20 (5.31%) as fixed dose combinations and 4 (1.06%) by generic names. Pantoprazole 183 (48.67%) was the most frequently prescribed drug for peptic ulcer in present study.

Conclusions: From the findings of this study we noted that among the GI drugs used, those for peptic ulcer were the most commonly prescribed. Also majority were from the essential drug list. But prescribing by generic names was low. Review of drug utilization trends is a necessary aid to formulate and modify existing protocols and guidelines to improve treatment outcomes in a given setting.

References

Dhawan P, Desai H. Prevention of gastrointestinal diseases. Natl Med J India. 1996;9(2):72-75.

Williams J, Roberts S, Ali F, Cheung W, Cohen D, Demery G et al. Gastroenterology services in the UK. The burden of disease, and the organisation and delivery of services for gastrointestinal and liver disorders: a review of the evidence. Gut. 2007;56(suppl_1):1-113.

Goh KL. Changing trends in gastrointestinal disease in the Asia–Pacific region. Jo Dig Dis. 2007 Nov;8(4):179-85.

John L, Padmini D, Shoba G. Utilization Profile of Gastrointestinal Medications among the Critically Ill Patients of A Tertiary Care Hospital. Jordan J Pharmaceuti Sci. 2013;6(3):299-306.

Aljarari NMH, Sharif SI, Jaber AK, Garini AS, Awad AS, Hamed FA. Prescribing patterns of gastrointestinal drugs in private clinics in Benghazi-Libya. Int J Basic Clin Pharmacol. 2017;6:113-6.

Ramesh L. Study of drug prescriptions in medical in-patients in a teaching hospital. Int J Basic Clin Pharmacol. 2016;5:2630-3.

Introduction to Drug Utilization Research: Chapter 3: Sources of data on drug utilization: 3.4 Practice setting data: 3.4.1 Prescribing data. Available at: http://apps.who.int/medicinedocs/en/d/Js4876e/4.4.1.html. Accessed 9 October 2018.

National List of Essential Medicines (NLEM) 2015 - India. Available at: http://apps.who.int/medicinedocs/en/d/Js23088en/. Accessed 12 September 2018.

Neupane P, Giri P, Nagalatha D. A Study on Prescribing Pattern of Proton Pump Inhibitors at A Private Tertiary Care Hospital. Am J Pharm Health Res. 2016;4(4):54-68.

Kaur S, Rajagopalan S, Kaur N, Shafiq N, Bhalla A, Pandhi P, Malhotra S. Drug utilization study in medical emergency unit of a tertiary care hospital in North India. Emergency Med Int. 2014;2014.

Gupta R. Drug prescribing pattern in intensive care unit (ICU) in a tertiary care teaching hospital in Central India. Int J Pharm Bio Sci. 2015;6(3):325-9

Mafauzy M. The problems and challenges of the aging population of Malaysia. Malaysian J Med Sci. 2000 Jan;7(1):1.

Mamatha V, Parashivamurthy BM, Suneetha DK. Study of drug utilization pattern in emergency medicine ward at a tertiary care teaching hospital. Int J Basic Clin Pharmacol. 2017;6:868-73.

Brunton L, Knollmann B, Hilal-Dandan R. Goodman & Gilman's the pharmacological basis of therapeutics. 13th ed. McGraw-Hill Education; 2017.

Rambhade S, Shrivastava A, Rambhade A, Chakarborty A, Patil U. A survey on polypharmacy and use of inappropriate medications. Toxicol Int. 2012;19(1):68.

Steinman M, Chren M, Landefeld C. What’s in a Name? Use of Brand versus Generic Drug Names in United States Outpatient Practice. J General Internal Med. 2007;22(5):645-648.

Kumar R, Bajaj JK, Sood M, Grewal N, Jassal B. To study prescription behaviour of physician in regard to brand and generic name. Int J Basic Clin Pharmacol. 2016;5:1327-30.

Pan F, Chernew M, Fendrick A. Impact of Fixed-Dose Combination Drugs on Adherence to Prescription Medications. J General Internal Med. 2008;23(5):611-4.

Meena VK, Atray M, Agrawal A. Evaluation of Drug Utilization Pattern In Indoor Patients Of Medicine Department At Tertiary Care Teaching Hospital In Southern Rajasthan. IJPSR. 2016 Sep 1;7(9):3835-40.

Arathy R, Chacko J, Pillai S, Bhanu A, Raphael R, Jalajakumari M. Drug utilisation in medical intensive care unit: a retrospective analysis from a tertiary care teaching hospital. Int J Basic Clin Pharmacol. 2016;5(4):1201-4.

Patka J, Wu DT, Abraham P, Sobel RM. Randomized controlled trial of ondansetron vs. prochlorperazine in adults in the emergency department. Western J Emergency Med. 2011 Feb;12(1):1.

Braude D, Crandall C. Ondansetron versus promethazine to treat acute undifferentiated nausea in the emergency department: a randomized, double‐blind, noninferiority trial. Academic Emergency Med. 2008 Mar;15(3):209-15.

Isolauri E. Probiotics for infectious diarrhoea. Gut. 2003 Mar 1;52(3):436-7.

Downloads

Published

2019-03-23

How to Cite

Kerkar, S. S., & Bhandare, P. N. (2019). Analysis of gastrointestinal drugs in patients admitted in CCU and ICCU of a tertiary care hospital in Goa, India. International Journal of Basic & Clinical Pharmacology, 8(4), 782–787. https://doi.org/10.18203/2319-2003.ijbcp20191117

Issue

Section

Original Research Articles