To compare and evaluate the anti-inflammatory efficacy of terminalia arjuna (aqueous extract of bark) with diclofenac sodium on rats

Authors

  • Maninder Singh Rana Department of Pharmacology, Maharishi Markendeshwar Institute of Medical Sciences and Research Mullana, Ambala, Haryana, India
  • Rani Walia Department of Pharmacology, Maharishi Markendeshwar Institute of Medical Sciences and Research Mullana, Ambala, Haryana, India
  • Alok Dixit Department of Pharmacology, Maharishi Markendeshwar Institute of Medical Sciences and Research Mullana, Ambala, Haryana, India
  • Kaustubh Raina Department of Pharmacology, Maharishi Markendeshwar Institute of Medical Sciences and Research Mullana, Ambala, Haryana, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20161502

Keywords:

Carrageenan, Diclofenac sodium, Flavonoids, Terminalia arjuna

Abstract

Background: Terminalia arjuna is a well-known Indian medicinal plant whose bark is extensively used in ayurvedic medicine. It is one of the most versatile medicinal plants having a wide spectrum of biological activity. The objective of this study was to study and evaluate the anti-inflammatory activity of Terminalia arjuna on carragennan induced paw edema in sprague dwaley rats.

Methods: Terminalia arjuna aqueous extract of bark in 200, 400 and 800mg/kg doses were administered to sprague dawely rats prior to induction of carrageenan induced paw edema. Statistical analysis: was done by using student t test. P < 0.05 was considered statistically significant.

Results: Only 400mg/kg dose of Terminalia arjuna aqueous extract of bark was able to decreases the size of paw edema at significant levels in carrageenan induced paw edema in rats.

Conclusions: The aqueous extract of bark of Terminalia arjuna possesses anti-inflammatory activity on carrageenan induced paw edema in rat model.

References

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Published

2016-12-30

How to Cite

Rana, M. S., Walia, R., Dixit, A., & Raina, K. (2016). To compare and evaluate the anti-inflammatory efficacy of terminalia arjuna (aqueous extract of bark) with diclofenac sodium on rats. International Journal of Basic & Clinical Pharmacology, 5(3), 692–695. https://doi.org/10.18203/2319-2003.ijbcp20161502

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Original Research Articles