Published: 2016-12-30

To compare and evaluate the anti-inflammatory efficacy of terminalia arjuna (aqueous extract of bark) with diclofenac sodium on rats

Maninder Singh Rana, Rani Walia, Alok Dixit, Kaustubh Raina


Background: Terminalia arjuna is a well-known Indian medicinal plant whose bark is extensively used in ayurvedic medicine. It is one of the most versatile medicinal plants having a wide spectrum of biological activity. The objective of this study was to study and evaluate the anti-inflammatory activity of Terminalia arjuna on carragennan induced paw edema in sprague dwaley rats.

Methods: Terminalia arjuna aqueous extract of bark in 200, 400 and 800mg/kg doses were administered to sprague dawely rats prior to induction of carrageenan induced paw edema. Statistical analysis: was done by using student t test. P < 0.05 was considered statistically significant.

Results: Only 400mg/kg dose of Terminalia arjuna aqueous extract of bark was able to decreases the size of paw edema at significant levels in carrageenan induced paw edema in rats.

Conclusions: The aqueous extract of bark of Terminalia arjuna possesses anti-inflammatory activity on carrageenan induced paw edema in rat model.


Carrageenan, Diclofenac sodium, Flavonoids, Terminalia arjuna

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Kumar DS, Prabhakar YS. On the ethnomedical significance of the Arjun tree. J Ethano pharmacol. 1987;20:173-90.

Morshed MA, Azim U, Rahman A, Hasan T, Roy S, Amin A, et al. Antimicrobial and cytotoxicity screening of Terminalia arjuna ethanol extract. Inter J Biol. 2011;1:31-8.

Chopra RN, Chopra IC, Handa KL, Kapur LD. Terminalia arjuna W and A (combertaceae). In: Chopra, RN, Chopra IC, Handa KL, Kapur LD (Eds.) Chopra’s Indigenous Drugs of India, 1st ed. UN Dhur and Sons, Calcutta, India; 1958:421-424.

Hemalatha T, Sivasami P, Balachandran C. Arjunolic acid a noval phytomedicine with multifunctional therapeutic applications. Indian J Exp Biol. 2010;48:238-47.

Miliani FL, Nielson OH, Andersen PS, Girardin SE. Chronic inflammation: importance of NOD2 and NALP3 in interleukin 1 beta generation. Clin Exp Immunol 2007;147(2):227-35.

Halder S, Bharal N, Mediratta PK, Kaur I, Sharma KK. Anti-inflammatory, immunomodulatory and antinociceptive activity of terminalia arjuna Roxb bark powder in mice and rats. Indian J Exp Biol 2009;47(7):577-83.

Kirtikar KR, Basu BD. Terminalia arjuna. In: Kirtikar KR, Basu BD. Editor. Indian Medicinal Plants.II. II. Allahabad, India, Lalit Mohan Basu Publication; 1935:1023-1028.

Silva GN, Martins FR, Matheus ME. Investigation of anti-inflammatory and antinociceptive activities of Lantana trifolia. J Ethanopharmacol. 2005;100:254-9.

Perianayagam JB, Sharma SK, Pillai KK. Anti-inflammatory activity of trichodesma indicum root extract in experimental animals. J Ethano pharmacol. 2006;2:410-4.

Sawadogo WR, Boly R, Lompo M, Some N, Lamien CE, Guissou IP, et al. Anti-inflammatory, analgesic and antipyretic activities of Dicliptera verticillata. Int J Pharmacol. 2006;2:435-8.

Wu JH, Tung YT, Chien SC, Wang SY, Kuo YH, Shyur LF, et al. Effect of phytocompoundes from the heart wood of acacia confuse on inflammatory mediators production. J Agric Food Chem. 2008;56:1567-73.