DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20191574

Comparative evaluation of adherence to antiretroviral therapy

Ritika Singla, Neetu Sharma

Abstract


Background: While treating  patients with HIV infection it is important to achieve more than 95% compliance to ART (Antiretroviral Therapy) in order to suppress viral replication.

Methods: This was a retrospective, observational, record based study of HIV positive patients undergoing treatment with ZLN (zidovudine 300 mg, lamivudine 150 mg, nevirapine 200 mg) and TLE ( tenofovir 300 mg, lamivudine 150 mg, efavirenz 600 mg) regimens. The treatment charts of the patients fulfilling inclusion and exclusion criteria were reviewed.

Results: Analysis of adherence showed that there were 12 patients out of 150 on ZLN regimen and 31 patients out of 150 on TLE regimen were nonadherent to the respective treatments.

Conclusions: In this observational study patients on ZLN regimen were showing greater compliance than TLE regimen.


Keywords


Adherence, Anti retroviral treatment, TLE, ZLN

Full Text:

PDF

References


Collier AC, Coombs RW, Schoenfeld DA, Bassett RL, Timpone J, Baruch A, et al. Treatment of human immunodeficiency virus infection with saquinavir, zidovudine, and zalcitabine. AIDS Clinical Trials Group. N Engl J Med. 1996;334:1011-7.

D'Aquila RT, Hughes MD, Johnson VA. Fischl MA, Sommadossi JP, Liou. et al. Nevirapine, zidovudine, and didanosine compared with zidovudine and didanosine in patients with H1V-1 infection. A randomized, double-blind, placebo-controlled trial. Ann Internal Med. 1996;124:1019-30.

Staszewski S, Miller V, Rehmet S, Stark T, De Crée J, De Brabander M, et al Virological and immunological analysis of a triple combination pilot study with loviride, lamivudine and zidovudine in HIV-1-infected patients. AIDS. 1996;10(5):F1-7.

Pujari S, Patel A, Joshi SR, Gangakhedkar R, Kumarasamy N. Guidelines for use of antiretroviral therapy for HIV infected individuals in India (ART guidelines 2008). JAPI. 2008 May;56.

Sahay S, Reddy KS, Dhayarkar S. Optimizing adherence to antiretroviral therapy. Indian J Med Res. 2011;134:835-49.

Osterberg L, Blaschke T. Adherence to Medication. N Engl J Med. 2005;353:487-97.

Paterson DL, Swindells S, Mohr J, Brester M, Vergis EN, Squier C, et al. Adherence to protease inhibitor therapy and outcomes in patients with HIV infection. Ann Internal Med. 2000;133(1):21-30.

Sodergard B, Halvarsson M, Tully MP, Mindouri S, Nordstrom L, Lindback S, et al. Adherence to treatment in Swedish HIV infected patients. J Clin Pharm Therapeutics. 2006;31:605-16.

Hemasri M, Sudhapoornima P, Sowmya Sri CH, Ramya S, Avinash I, Kumar KB. Safety and effectiveness of anti-retroviral drug regimens Zln and Tle in tertiary care teaching hospital: a prospective observational study. J Pharma Biol Sci. 2016:11(2):88-96.

French M, Amin J, Roth N, Carr A, Law M, Emery S et al. Randomised, open-label, comparative trial to evaluate the efficacy and safety of three antiretroviral drug combination including two nucleoside analogues and nevirapine for previously untreated HIV-1 infection: the OzCombo 2 Study. HIV Clin Trials. 2002;3(3):177-85.

Rajput JS, Mathur MK, Chaurasia AK, Singh S, Tiwari A. The effect of nevirapine vs efavirenz containing regimens on clinical outcomes among HIV patients on ART: a comparative study. Int J Adv Med. 2017;4(3):768-71.