Anti-tumor effect of fruit rind of Myristica malabarica in an Ehrlich ascites carcinoma model

Authors

  • Chandrakana Bandyopadhyay Department of Pharmacology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India
  • Alak Manna Department of Pharmacology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India
  • Soumita De Department of Pharmacology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India
  • Nafisha Yasmin Department of Pharmacology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India
  • Ajay K. Bauri Bio-Organic Division, Bhaba Atomic Research Centre, Trombay, Mumbai, Maharashtra, India
  • Subrata Chattopadhyay Bio-Organic Division, Bhaba Atomic Research Centre, Trombay, Mumbai, Maharashtra, India
  • Mitali Chatterjee Department of Pharmacology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20190648

Keywords:

Anti-tumor, Ehrlich ascites carcinoma, Malabaricones, Myristica malabarica, Rampatri

Abstract

Background: Among the various modalities of anti-cancer treatment, cancer chemotherapy plays a very vital role. The alarming side effects being its main drawback leads to relentless research for newer agents. A new natural agent with promising anti-cancer properties from in-vitro studies leads to this study. Here we have evaluated the anti-tumor activity of a crude extract of fruit rind of Myristica malabarica in an Ehrlich ascites carcinoma model in mice.

Methods: A murine model of cancer was established with i.p. inoculation of Ehrlich Ascites carcinoma (EAC) cells; animals were divided into five groups (including normal control) to observe the inhibitory effect of a crude extract of the fruit rind of Myristica malabarica/rampatri (0-100mg/kg b.w. i.p.) as compared with methotrexate (0.4mg/kg bw., i.p.). Blood and ascitic fluid were collected on the 10th day for analysis.

Results: In the EAC model, there was an increase in tumor volume, tumor weight, and tumor packed cell volume, which was decreased by rampatri (50 and 100mg/kg bw) along with an increase in the mean survival time (MST). Rampatri caused minimal alterations in hematological parameters, renal functions remained unchanged but an increase in hepatic SGOT was demonstrated.

Conclusions: The crude extract of rampatri (containing Malabaricones) exhibited significant anti-tumor activity with minimal effect on hematological and renal functions.

References

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Published

2019-02-23

How to Cite

Bandyopadhyay, C., Manna, A., De, S., Yasmin, N., Bauri, A. K., Chattopadhyay, S., & Chatterjee, M. (2019). Anti-tumor effect of fruit rind of Myristica malabarica in an Ehrlich ascites carcinoma model. International Journal of Basic & Clinical Pharmacology, 8(3), 383–387. https://doi.org/10.18203/2319-2003.ijbcp20190648

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Original Research Articles