Clonidine, dexmedetomidine: alpha-2 adrenergic receptor agonists in neuroscience

Authors

  • Jabril B. Eldufani Department of Medicine, University of Montreal, Montreal, Quebec, Canada
  • Nyruz R. Elahmer Department of Pharmacology and Physiology, University of Montreal, Montreal, Quebec, Canada
  • Alireza Nekoui Department of Medicine, University of Montreal, Montreal, Quebec, Canada
  • Gilbert A. Blaise Department of Medicine, University of Montreal, Montreal, Quebec, Canada Department of Anesthesiology and Pain Management, Management, University Hospital of Montreal (CHUM), Montreal, Quebec, Canada

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20184870

Keywords:

α-2 AR agonists, Cognitive, Depression, Immune system, Pain, Sleep

Abstract

The alpha-2 adrenergic receptor (α-2 AR) agonists have a long history of use in treating different clinical conditions, such as hypertension, psychiatric entities (e.g., attention-deficit hyperactivity disorder), chronic pain, panic disorders, and, lately, for treating opioid withdrawal syndrome. In recent years, α-2 AR medications have been administered as adjuncts for managing inflammatory conditions, depression, chronic pain, sleep and cognitive disorders. This review will provide some clinical applications in neuroscience for this class of drugs. Understanding the pharmacological mechanisms is essential to obtaining neurochemical data that demonstrate that α-2 AR agonists have potential clinical significance in neuroscience.

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Published

2018-11-24

How to Cite

Eldufani, J. B., Elahmer, N. R., Nekoui, A., & Blaise, G. A. (2018). Clonidine, dexmedetomidine: alpha-2 adrenergic receptor agonists in neuroscience. International Journal of Basic & Clinical Pharmacology, 7(12), 2476–2482. https://doi.org/10.18203/2319-2003.ijbcp20184870

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Section

Review Articles