Efficacy of 5HT3 receptor antagonist ondansetron antidepressant activity in physical induced albino mice

Authors

  • Janardhan Marupaka Department of Pharmacology, Rajiv Gandhi Institute of Medical Sciences (RIMS), Adilabad, Telangana, India
  • Roopa B. Department of Pharmacology, RVM Institute of Medical Sciences and Research Centre, Laxmakkapally, Mugulu, Medak, Telangana, India
  • Naveen Kumar T. Department of Pharmacology, Apollo Institute of Medical Sciences and Research, Hyderabad, Telangana, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20183942

Keywords:

Antidepressant activity, Albino mice, Ondansetron, Physical induced

Abstract

Background: The objective of this study was to evaluate efficacy of 5HT3 receptor antagonist ondansetron antidepressant activity in physical induced swiss albino mice.

Methods: Study was placebo controlled, randomized laboratory based comparative study with prior permission of Institutional animal ethical committee. Experimental animals were divided in to seven groups as control (distilled water 10ml/kg), standard Fluoxetine two doses (10mg/kg and 20mg/kg) , test drug ondansetron three doses (0.5mg/kg, 1mg/kg and 2mg/kg) and combinations of test and standard (0.5mg/kg + 10mg/kg).The drugs were administered intraperitonium and antidepressant activity was recorded using physically induced depression models tail suspension test and despair swim test.

Results: Ondansetron treated albino mice groups with dose dependent increase of 0.5mg/kg, 1.0mg/kg and 2.0mg/kg showed significant decrease in antidepressant activity and increase in catalepsy score when compared with fluoxetine 10mg/kg and 20mg/kg. Combination doses showed stastically significant antidepressant activity.

Conclusions: The present study indicates ondansetron showed promising antidepressant activity due to its ability to modulate serotonergic system and has proved to be safe in the dose range of 0.5mg/kg, 1mg/kg and 2mg/kg in mice.

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Published

2018-09-24

How to Cite

Marupaka, J., B., R., & T., N. K. (2018). Efficacy of 5HT3 receptor antagonist ondansetron antidepressant activity in physical induced albino mice. International Journal of Basic & Clinical Pharmacology, 7(10), 2028–2030. https://doi.org/10.18203/2319-2003.ijbcp20183942

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Original Research Articles