DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20150892

A novel rapid - acting oral inhalation human insulin for diabetes mellitus: Afrezza

Ravindra S. Beedimani, Shivkumar G. Shetkar

Abstract


Afrezza is rapid-acting oral inhalation insulin that is administered at the beginning of each meal. The U.S Food and Drug Administration has approved Afrezza (insulin human) inhalation powder, a rapid-acting inhaled insulin to improve glycemic control in adults ≥18 years of age with Type 1 or Type 2 diabetes mellitus (T1DM or T2DM). Afrezza must be used in combination with long-acting insulin in patients with T1DM. Afrezza may be used with either oral anti-diabetic drugs or basal insulin in patients with T2DM. Afrezza should be administered via oral inhalation using Afrezza inhaler. Dosage adjustment is needed when switching from injection insulin to oral inhalation Afrezza. It is contraindicated in individuals with chronic lung disease and smokers because of the risk of the acute bronchospasm. Before initiating, Afrezza, a complete medical history, physical examination and spirometry (forced expiratory volume 1 sec) results is required in all individuals to identify the potential lung disease. Common adverse reactions in individuals treated with Afrezza include hypoglycemia, cough, throat pain or irritation, headache, and diarrhea.


Keywords


Afrezza, Type 1 diabetes mellitus, Type 2 diabetes mellitus, Rapid-acting human insulin analog, Regular-human insulin

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References


Baran MK, Godoy AT. What went wrong? A retrospective on Exubera. Adv Nurse Pract. 2008;16(11):53-4, 77.

Klonoff DC. Afrezza inhaled insulin: the fastest-acting FDA-approved insulin on the market has favorable properties. J Diabetes Sci Technol. 2014;8(6):1071-3.

Rendell M. Technosphere inhaled insulin (Afrezza). Drugs Today (Barc). 2014;50(12):813-27.

Nuffer W, Trujillo JM, Ellis SL. Technosphere insulin (Afrezza): a new, inhaled prandial insulin. Ann Pharmacother. 2015;49(1):99-106.

Kling J. Sanofi to propel inhalable insulin Afrezza into market. Nat Biotechnol. 2014;32(9):851-2.

Neumiller JJ, Campbell RK, Wood LD. A review of inhaled technosphere insulin. Ann Pharmacother. 2010;44(7-8):1231-9.

Neumiller JJ, Campbell RK. Technosphere insulin: an inhaled prandial insulin product. BioDrugs. 2010;24(3):165-72.

Mastrandrea LD. Inhaled insulin: overview of a novel route of insulin administration. Vasc Health Risk Manag. 2010;6:47-58.

Rashid J, Absar S, Nahar K, Gupta N, Ahsan F. Newer devices and improved formulations of inhaled insulin. Expert Opin Drug Deliv. 2014;8:1-12.