Published: 2017-12-23

To assess awareness regarding rational drug therapy and fixed dose combinations amongst interns and II MBBS students in tertiary care teaching hospital in Maharashtra, India

Jeetendra M. Singh, Tushar C. Baheti, Rakesh Verma


Background: The present study was designed to assess awareness regarding rational drug therapy and fixed dose combinations (FDC) amongst interns and II MBBS students in a tertiary-care teaching hospital in Maharashtra, India.

Methods: This cross-sectional, questionnaire-based study containing MCQ and analytical questions on rational drug therapy, fixed dose combinations and role of Pharmacist in dispensing correct drug to the patients was carried out in both interns (n=80) and II MBBS students (n=100). The completed questionnaires were then collected and analysed statistically for responses.

Results: Mean average score obtained by II MBBS students (score - 36.66marks) was significantly better than interns (score- 20marks) which probably may be due to pharmacology teaching they were undergoing. II MBBS students were found to be better informed as compared to the interns (p<0.05) on questions related to rational drug therapy. On the questions related to rationality of FDC in Yes/No type, interns and II MBBS students were found to be equally informed (p>0.05). However, on question related to justification of FDC, interns were found to be better informed as compared to the II MBBS students (p<0.05). On single question pertaining to role of pharmacist, interns were found to be better informed than II MBBS students possibly due to their better understanding of patient-pharmacist relationship.

Conclusions: Our study highlights the significance regarding knowledge of rational drug therapy and fixed dose combination (both rational and irrational), both rational and irrational, amongst both interns and II MBBS students while identifying the possible areas of interventions to make them rational clinicians.


Fixed dose combinations, Interns, MBBS students, Rational drug therapy, Questionnaire

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Poudel A, Palaian S, Shankar PR, Jayasekera J, Izham MIM. Irrational fixed dose combinations in Nepal: Need for intervention. Kathmandu Univ Med J. 2008;23:399-405.

Amitava S. Indian market's fixation with fixed dose combinations. Rational Drug Bulletin. 2002;12:1.

Gautam CS, Aditya S. Irrational drug combinations: Need to sensitise undergraduates. Indian J Pharmacology. 2006;38(3):169-70.

Tripathi KD. Aspects of pharmacotherapy: Essentials of medical pharmacology 7th Ed. New Delhi. Jaypee Brothers medical Publishers Ltd; 2013:61-73.

Holloway K. Promoting rational use of medicines. Contact a publication of world council of churches. 2006;183:2-3.

Bergman U, Wiholm BE. Drug-Related Problems Causing Admission to a Medical Clinic. Euro J Clin Pharmacol. 1981;20:193-200.

Kingsbury SJ, Yi D, Simpson GM. Psychopharmacology: rational and irrational polypharmacy. Psychiatric Services. 2001;52(8):1033-6.

Islam MS. A Review on the Policy and Practices of Therapeutic Drug Uses in Bangladesh. Calicut Medical Journal. 2006;4(4):e2.

Sneha A, Mathur AK. Rational Drug Use. Health Administrator 2006; 19(1): 5-7.

Esra C, Nazh SM, Philip CM. Factors Affecting Rational Drug Use (RDU), Compliance and Wastage. Turkish Journal of Pharmaceutical Sciences 2013;10(1):151-70.

Ellis A. Prescribing rights: Are medical students properly prepared for them? BMJ. 2002;324:1591.

De Vries TP, Henning RH, Horgerzeil HV, Fresle HV. World Health Organization: Guide to good prescribing. Geneva: WHO. 1994;14-8.

Naik M, Nerurkar R, Phatak A, Panchal S, Paunikar A. A questionnaire-based study to assess rational prescribing practice among interns. Natl J Physiol Pharm Pharmacol. 2015;5:323-7.

Hilmer SN, Seale JP, Le Couteur DG. Do medical courses adequately prepare interns for safe and effective prescribing in New South Wales public hospitals? Intern Med J. 2009;39(7):428-34.

Banerjee I, Bhadury T. Prescribing pattern of interns in a primary health center in India. J Basic Clini Pharm. 2014;5(2):40-3.