Study of drug utilization pattern and adverse drug reactions of psychotropic drugs in psychiatric inpatient department of tertiary care hospital

Aruna Gurung, Jugalkishore B. Jaju, Ganesh R. Pawar, Shrikant C. Dharmadhikari, Rajvardhan R. Solunke


Background: Mental disorders are now widely recognized as a major contributor to the global burden of disease. The drug use in psychiatric illness is a complex process and because of this the optimal benefits of drug therapy in patient care is not achieved. This often leads to increased cost of medical care, drug resistance, adverse effects and patient mortality. Hence, this study is undertaken to study the drug utilization pattern and adverse drug reactions of psychotropic drugs in psychiatric inpatient department of a tertiary care hospital.

Methods: A prospective, observational study was undertaken from 1st February 2015 to 31st July 2016. A total of 250 prescriptions were analysed. Defined daily dose of the drugs were calculated. ADR’s were recorded in the format of the National Pharmacovigilance Programme of India (PvPI).

Results: In 250 prescriptions most, common drug prescribed was antipsychotics (48.5%). Total drug utilization in terms of DDD/100 bed days was 669. The total number of adverse drug reactions observed was 8%. Antipsychotics were the most common class of psychotropic drugs causing ADR’s.

Conclusions: In conclusion, it has been found that the psychotropic drugs used in our psychiatry department was rational and was based on clinical knowledge, expertise and the guidelines available in the field of psychiatric practice.


Adverse drug reactions, Drug utilization pattern, Psychotropic drugs, Psychiatric inpatient

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WHO. The world health report 2001-Mental health new understanding, new hope, 2001. Available at: http// /whr/2001/en/. Accssed 12 August 2016.

Sachdeva PD, Patel BG. Drug utilization studies- scope and future perspectives. Int J Pharma Bio Res. 2010;1(1):11-7.

Dutta S, Atif BM, Kaul V, Dutta S, Dhasmana DC. Psychotropic drug utilization study in psychiatric OPD of a tertiary care teaching hospital in Dehradun, Uttarakhand. J Adv Res Bio Sci. 2013;5(4):386-91.

Sharma T, Vishwakarma K, Dhasmana DC, Gupta R. Adverse drug reaction monitoring in psychiatry outpatient department of a tertiary care teaching hospital. JK sci. 2014;16(4):156-60.

Patel MK, Barvaliya MJ, Patel TK, Tripathi CB. Drug utilization pattern in critical care unit in a tertiary care teaching hospital in India. Int J Crit Illn Inj Sci. 2013;3(4):250-5.

Mohanta GP. Assessment of adverse event report. In: Mohanta GP, Manna PK, eds. Textbook of Pharmacovigilance Concept and Practice.1st Edition. Hyderabad Pharma Med Press; 2016:29-55.

Thompson A, Shaw M, Harrison G, Verne J, Davidson HO, Gunnell D. Patterns of hospital admission for adult psychiatric illness in England: analysis of Hospital Episode Statistics data. B J Psych. 2004;185:334-41.

World Health Organisation, 2003. Introduction to drug utilization research, 2003. Available at: http// 12 August 2016.

Thakkar KB, Jain MM, Billa G, Joshi A, Khobragade AA. A drug utilization study of psychotropic drugs prescribed in the psychiatry outpatient department of a tertiary care hospital. J Clin Diagn Res. 2013;7(12):2759-64.

Srinivasan R, Ramya G. Adverse drug reaction-causality assessment. Int J Res Pharm Chem. 2011;1(3):606-12.

Joel JJ, Shastry CS, Rao S. Evaluation of antipsychotic drug prescriptions in hospitalized schizophrenic patients. Int J Pharma Res Bio-Sci. 2015;4(1):353-63.

Mittal N, Mittal R, Singh I, Shafiq N, Malhotra S. Drug Utilization Study in a Tertiary Care Center: Recommendations for Improving Hospital Drug Dispensing Policies. Indian J Pharm Sci. 2014;76(4):308-14.

Harichandran DT, Viswanathan MT, Gangadhar R. Adverse drug reactions among hospitalized patients in Psychiatry Department in a Tertiary Care Hospital. J Health Res Rev. 2016;3(2):77-80.

Prajapati HK, Joshi ND, Trivedi HR, Parmar MC, Jadav SP. Adverse Drug Reaction Monitoring in Psychiatric Outpatient Department of a Tertiary Care Hospital. Natl J Integr Res Med. 2013;4(2):102-6.

Sridhar SB, Faris SS, Jabbar TR. Monitoring of adverse drug reactions in psychiatry outpatient department of a Secondary Care Hospital of Ras Al Khaimah, UAE. J Basic Clin Pharma. 2016;7(3):80-6.