Elevated liver enzymes after olanzapine use: a case report

Authors

  • Samreen Ahmed Department of Psychiatry, Brookdale University Hospital and Medical Center, Brooklyn, New York, USA
  • Saima Warraich Department of Psychiatry, Brookdale University Hospital and Medical Center, Brooklyn, New York, USA

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20160130

Keywords:

Olanzapine, Liver enzymes, Bipolar mania

Abstract

Olanzapine is a second-generation antipsychotic used in bipolar mania and schizophrenia. We are reporting the case of a young female patient who developed elevated liver enzymes after olanzapine use. Patient's liver enzymes improved after the discontinuation of olanzapine making it a possible cause for reversible hepatotoxicity. We recommend physicians to check liver enzymes regularly if patient is on olanzapine.

References

Miyamoto S, Duncan GE, Marx CE, Lieberman JA. Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs. Mol Psychiatry. 2005;10(1):79-104.

Manceaux P, Constant E, Zdanowicz N, Jacques D, Reynaert C. Management of marked liver enzyme increase during olanzapine treatment: a case report and review of the literature. Psychiatr Danub. 2011;23(1):S15-17.

Divac N, Prostran M, Jakovcevski I, Cerovac N. Second generation antipsychotics and extrapyramidal adverse effects. BioMed Res Intl. 2014;2014. http://dx.doi.org/10.1155/2014/656370.

Tikka SK, Pratap A, Sinha VK. Dose-dependent Olanzapine-induced myolonus. Toxicol Int. 2014;21(3):335-6.

Sun Z, Wang X. Case report of refractory tardive dystonia induced by olanzapine. B Shanghai Arch Psychiatry. 2014;26(1):51-3.

Basu A, Kundu S, Khurana H. Olanzapine-induced restless leg syndrome: A case report and review of literature. Indian J Pharmacol. 2014;46:450-2.

Kerr TA, Jonnalagadda S, Prakash C, Azar R. Pancreatitis following olanzapine Therapy: A report of three cases. Case Rep Gastroenterol. 2007;1(1):15-20.

Tuglu C, Erdogan E, Abay E. Delirium and extrapyramidal symptoms due to a lithium-olanzapine combination therapy: A case report. J Korean Med Sci. 2005;20(4):691-4.

Olsson R, Zettergren L. Anticonvulsant-induced liver damage. Am J Gastroenterol. 1988;83(5):576-7.

Atasoy N, Erdogan A, Yalug I, Ozturk U, Konuk N, Atik L et al. A review of liver function tests during treatment with atypical antipsychotic drugs: a chart review study. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31(6):1255-60.

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Published

2016-12-24

How to Cite

Ahmed, S., & Warraich, S. (2016). Elevated liver enzymes after olanzapine use: a case report. International Journal of Basic & Clinical Pharmacology, 5(1), 213–214. https://doi.org/10.18203/2319-2003.ijbcp20160130