Can idiosyncratic drug reactions occur in quick succession? a case of cross sensitivity between levetiracetam and phenytoin

Authors

  • Chitralekha Anilkumar Nayak Department of Medicine, Goa Medical College and Hospital, Bambolim, Goa, India
  • Kalyani Pai Kakode Department of Pharmacology, Goa Medical College and Hospital, Bambolim, Goa, India
  • Padmanabh V. Rataboli Department of Pharmacology, Goa Medical College and Hospital, Bambolim, Goa, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20173304

Keywords:

Adverse drug reaction, Drug induced agranulocytosis, Idiosyncratic drug reaction, Levetiracetam, Phenytoin

Abstract

The occurrence of adverse drug reactions (ADRs) to more than one drug in quick succession can cause diagnostic dilemma to the doctor and increased burden of suffering to the patient. We present a single case report of a 23 year old female who developed rash and agranulocytosis in quick succession as ADRs to phenytoin and levetiracetam respectively. These antiepileptic drugs (AEDs) were prescribed as prophylaxis against post traumatic seizures (PTS). Hence a proper rationale for the prophylactic treatment of PTS and pharmacovigilance for early detection of adverse drug reactions is the need of the hour.

References

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Published

2017-07-22

How to Cite

Nayak, C. A., Kakode, K. P., & Rataboli, P. V. (2017). Can idiosyncratic drug reactions occur in quick succession? a case of cross sensitivity between levetiracetam and phenytoin. International Journal of Basic & Clinical Pharmacology, 6(8), 2098–2101. https://doi.org/10.18203/2319-2003.ijbcp20173304

Issue

Section

Case Reports