A comparative study of antinociceptive effect of paroxetine with pethidine in acute pain in albino rats

Authors

  • Manju Gari Department of Pharmacology, Rajendra Institute of Medical Sciences (RIMS), Ranchi University, Ranchi, Jharkhand, India
  • Kumari Ranjeeta Department of Pharmacology, Rajendra Institute of Medical Sciences (RIMS), Ranchi University, Ranchi, Jharkhand, India
  • Lakhan Majhee Department of Pharmacology, Rajendra Institute of Medical Sciences (RIMS), Ranchi University, Ranchi, Jharkhand, India
  • Akhilesh Kumar Department of Pharmacology, Rajendra Institute of Medical Sciences (RIMS), Ranchi University, Ranchi, Jharkhand, India
  • Sumit Kumar Mahato Department of Pharmacology, Rajendra Institute of Medical Sciences (RIMS), Ranchi University, Ranchi, Jharkhand, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20172739

Keywords:

Antinociception, Paroxetine, Selective serotonin reuptake inhibitors

Abstract

Background: Pain is the most common reason patients seek medical care. Increased level of monoamines (serotonin and norepinephrine) in synaptic clefts lead to changes in pain threshold and induce antinociception. The study was carried out to evaluate antinociceptive effect of paroxetine in albino rats and to probe into its possible mechanism of action. The study was carried out to evaluate anti-nociceptive effect of paroxetine in albino rats.

Methods: Male Albino rats of average weight 150-240gms were used. The drugs used were paroxetine 5mg/Kg, pethidine 5mg/kg (standard drug). Anti-nociceptive effect tested by using thermal method i.e. Tail flick response and Tail warm water immersion method.

Results: In this study, Anti-nociceptive effect of respective drugs were measured by using two methods i.e. tail flick test and tail warm water immersion method at 0 min., 30 min., 60 min. and 90min.after administration of drugs. Reaction time started to increase from baseline at 0 min. and peak effect was seen at 60 min. then it started to decrease at 90 min. in almost all the groups except in control group.

Conclusions: Paroxetine have significant analgesic effect in acute pain, which may be mediated via central and peripheral mechanisms. Efficacy of Paroxetine is almost equal to that of standard drug pethidine in acute pain management.

References

Monks. Psychotropic drugs. In: Bonica’s The Management of Pain, 2nd Edition, Williams and Wilkins, United States of America; 1990:1677-1679.

Jung AC, Staiger T, Sullivan M. The efficacy of selective serotonin reuptake inhibitors for the management of chronic pain. Journal of General Internal Medicine. 1997;12(6):384-96.

Pilowsky I, Hallett EC, Bassett DL, Thomas PG, Penhall RK. A controlled study of amitriptyline in the treatment of chronic pain. Pain. 1982;14:169-79.

Onghena P, Van Hondenhobe B. Antidepressant-induced analgesia in chronic nonmalignantpain: a meta-analysis of 39 placebo-controlled studies. Pain.1992;49:205-19.

Dick IE, Brochu RM, Purohit Y, Kaczorowski GJ, Martin WJ, Priest BT. Sodium Channel blockade may contribute to the analgesic efficacy of antidepressants. J Pain. 2006;14:315-24.

Choi JJ, Huang GJ, Shafik E, Wu WH, McArdle JJ. Imipramine’s selective suppression of an L-type calcium channel in neurons of murine dorsal root ganglia involves G proteins. J Pharmacol Exp Ther. 1992;263:49-53.

Chaplan SR, Pogrel JW, Yaksh TL. Role of voltage dependent calcium channel subtypes in experimental tactile allodynia. J Pharmacol Exp Ther. 1994;269:1117-23.

Valverde O, Mico JA, Maldonaldo R, Mellado M, Gilbert-Rahola J. Participation of opioid and monoaminergic mechanisms on the antinociceptive effect induced by tricyclic antidepressants in two behavioral pain tests in mice. Prog Neuropsychopharmacol Biol Psychiatry. 1994;18:1073-92.

Yokogawa F, Kiuchi Y, Ishikawa Y, Otsuka N, Masuda Y, Oguchi K, et al. An investigation of monoamine receptors involved in antinociceptive effects of antidepressants. Anesthesia and Analgesia. 2002;95(1):163-8.

Rumore MM, Schlichting DA. Clinical efficacy of antihistaminics as analgesics. Pain. 1986;25:7-22.

Gray AM, Spencer PS, Sewell RD. The involvement of the opioidergic system in the antinociceptive mechanism of action of antidepressant compounds. Br J Pharmacol. 1998;124:669-74.

Richelson E. Pharmacology of antidepressants, Mayo Clin. Proc. 2001;76:511-27.

Bourin M, Chue P, Guillon Y. Paroxetine: a review. CNS Drug Rev. 2001;7:25-47.

Richelson E. Pharmacology of antidepressants. Mayo Clin Proc. 2001;76:511-27.

Jung AC, Staiger T, Sullivan M. The efficacy of selective serotonin reuptake inhibitors for the management of chronic pain. J Gen Intern Med. 1997;12:384-9.

Korzeniewska-Rybicka I, Plaznik A. Analgesic effect of antidepressant drugs. Pharmacol Biochem Behav. 1998;59:331-8.

Coquoz D, Porchet HC, Dayer P. Central analgesic effects of desipramine, fluvoxamine and moclobemide after single oral dosing: a study in healthy volunteers. Clin Pharmacol Ther. 1993;54:339-44.

Yatish B, Nadia N, Patil VM. Study of antinociceptive effect of paroxetine in acute pain in albino rats. Int J Basic Clin Pharmacol. 2016;5(3):1022-8.

Erdem D, Murat K, Mine K, Cunay U, Nuri K, Ersin Y. Effect of gender on antinociceptive effect of paroxetine in hot plate test in mice Progneuro psycho pharmacol Biol Psychatr. 2006;30(2):292-6.

Ghosh MN. Toxicity studies In. Ghosh MN, editor, Fundamental of Experimental Pharmacology 5th Ed, Kolkata; Hilton and company; 2011:167-209.

Mann MD, Crouse DA, Prentice ED. Appropriate Anomal numbers in Biomedical Research in Light of Animal Welfare Considerations, Laboratory Animal Science. 1991;41(1):6-14.

D'Amour FE, Smith DL. A method for determining loss of pain sensation (PDF). J Pharmacol Exp Ther. 1941;72(1):74-8.

Ramabadran K, Bansinath M, Turndorf H, Puig MM. Tail immersion test for evaluation of a nociceptive reation in mice. J Pharmacol Meth. 1989;21:21-31.

Duman EN, Kesim M, Kadioglu M, Yaris E, Kalyoncu NI, Erciyes N. Possible involvement of opioidergic and serotonergic mechanisms in antinociceptive effect of paroxetine in acute pain J Pharmacol Sci. 2004 Feb;94(2):161-5.

Umamaheshwari C, Shanthi M, Malathi M, Parameswari R. Evaluation of Analgesic Activity of Paroxetine in Adult Male Albino Rats in Comparison with Diclofenac International Journal of Science and Research (IJSR). 2016 May;5(5).

Patil R, Myageri RL, Geetha. Study of Antinociceptive Effect of Paroxetine and Elucidation of Its Mechanism of Action in Acute Pain in Albino Rats, Drug Invention Today. 2012;4(6):379-80.

Masand PS, Narasimhan M, Patkar AA. Paroxetine for somatic pain associated with physical illness: A review, Prim. Care Companion J Clin Psychiatry. 2006;8:122-30.

Gray AM, Spencer PSJ, Sewell RDE. The involvement of the opioidergic system in the antinociceptive mechanism of action of antidepressant compounds, Br. J. Pharmacol. 1998;124:669-674,187.

Singh VP, Jain NK, Kulkarni SK. On the antinociceptive effect of fluoxetine, a selective serotonin reuptake inhibitor. Brain Res. 2001;915:218-26.

Auerbach S, Fornal C, Jacobs BL. Response of serotonincontaining neurons in nucleus raphe magnus to morphine, noxious stimuli, and periaqueductal gray stimulation in freely moving cats. Exp Neurol. 1985;88:609-28.

Iyengar S, Webster AA, Hemrick-Luecke SK, Xu JY, Simmons RM. Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats, J Pharmacol Exp Ther. 2004 Nov;311(2):576-84.

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Published

2017-06-23

How to Cite

Gari, M., Ranjeeta, K., Majhee, L., Kumar, A., & Mahato, S. K. (2017). A comparative study of antinociceptive effect of paroxetine with pethidine in acute pain in albino rats. International Journal of Basic & Clinical Pharmacology, 6(7), 1728–1732. https://doi.org/10.18203/2319-2003.ijbcp20172739

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Original Research Articles