DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20171505

Toxicity profile of thal-dex regime in patients with multiple myeloma

Dawnji S. R., Reeja R., Rakesh Praveen Raj M. R.

Abstract


Background: To study the spectrum, incidence and severity of toxicity among Multiple Myeloma patients receiving Thal-Dex in South Indian population.

Methods: Between November 2005 and November 2005, 25 adult patients with previously- untreated Multiple Myeloma were assigned to receive Thal-Dex at Regional Cancer Centre, Trivandrum. During chemotherapy, patients were followed-up to detect the development of any toxicity symptoms. The toxicities recorded, were graded according to the criteria of the World Health Organization toxicity-guidelines.

Results: In the 25 patients who received Thal-Dex, peripheral neuropathy, infection and constipation were significantly seen, while gastrointestinal toxicities were seen to a lesser extent, and haematological toxicities were low.

Conclusions: The Thal-Dex regimen was tolerated well by majority of the patients and showed favourable toxicity profile, reiterating its acceptability as a front line antimyeloma regimen


Keywords


Dexamethasone, Multiple myeloma, Thal-Dex toxicity, Thalidomide

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