DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20170833

Evaluation of anticonvulsant activity of amlodipine in albino rats

Roopa B., Janardhan M., Venkata Rao Y.

Abstract


Background: The objective of the study was to evaluate the anticonvulsant activity of amlodipine in albino rats.

Methods: Anticonvulsant activity of amlodipine was done in three graded doses (1 mg/kg, 2 mg/kg, 4 mg/kg), and combination group with low dose of amlodipine (1 mg/kg) and standard drug (phenytoin) in maximal electroshock seizures (MES) experimental animal model.

Results: Amlodipine in dose of 2, 4 mg/kg showed dose dependent significant anticonvulsant effect and combination of low dose amlodipine and low dose of standard drug also showed significant anticonvulsant effect in MES model.

Conclusions: Amlodipine is having anticonvulsant activity and also potentiated the anticonvulsant effect of phenytoin in MES model.

 


Keywords


Amlodipine, Anticonvulsant, Maximal electroshock seizures, Phenytoin

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