Evaluation of cost effectiveness and efficacy of commonly used different antacid gel preparations

Vedavathi H, Tejasvi T S, Shreenivas P. Revankar

Abstract


Background: Gastroesophageal reflux disease (GERD) is a common clinical condition in Indian population. Antacids, which are available as over the counter (OTC) are the commonly prescribed drugs for treatment of GERD. Antacids manufactured and marketed by various multinational and local companies are available in the market. There is need for evaluating the cost effectiveness and efficacy of these antacids as a matter of public concern. Hence the present study was conducted to evaluate the cost effectiveness and efficacy of the commonly prescribed antacid gel preparations.

Methods: Seven different gel formulations of antacids manufactured by different companies were evaluated. Cost effectiveness was done by calculating the cost per ml of antacid and also by palatability test. Efficacy was evaluated based on acid neutralizing capacity (ANC) of antacid preparations.

Results: The highest cost was 0.305 Rs. per ml and lowest was 0.135 Rs per ml. Palatability score was high at 26.80 and low at 23.85. The antacid with lowest ANC was 20.5 mEq and the highest was 26.5 mEq.

Conclusion: Cost effectiveness studies are beneficial in improving the prescribing pattern. It will be a benefit for both doctor as well as patient.


Keywords


Antacids, Cost effectiveness, Efficacy, Palatability, Acid neutralizing capacity

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References


Fauci, Braunwald, Kasper, Hauser, Lango, Jameson, Loscalzo. Harrison’s principals of internal medicine.17th Ed; vol (2):1851-52.

Vakil N, Vanzanten S V, Kanrilas P, Dent J, Jones R. The Montreal definition and classification of Gastroesaphageal reflux disease. A global evidence based consciousness; Am J Gastroenterology 2006; 101:1900-20.

Ramu B, Mohan P, Rajasekharan MS, Jayanthi V. Prevalence and risk factor for Gastroesophageal reflux in pregnancy. Indian J Gastroenterol. 2011;30:144-7.

Caranosos GJ, Stewart RB, Cluff LE. Clinically desirable drug interactions. Annual Review of Pharmacology and Toxicology.1985;25:67-95.

Schulthen HK. Antacid-gel or tablet, a randomized double-blind, placebo controlled study. Schweiz med wochenschr. 1985;115(29):1069.

Suvarna Bhoir, Bhagwath AM. Comparison of seven oxethazine containing antacids available in Indian market. JAPI 2013;61:400-403.

David Drake, Daniel Hollander. Neutralizing capacity and cost effectiveness of antacids. Ann Internal Med. 1981;94(2):215-17.

Thomson AR, Pinchbeck B, Kirdeikis J, Kirdekis P, Zuk L, Burnet K. Evaluation of antacid tablets and liquids in fasting and fed men and women. Clin Ther 1988;10:158-168.

John S, Fordtran MD, Stephan G, Morawaski BA, Charles T, Richardson MD. Invivo and invitro evaluation of liquid antacids. NEJM 1973;288:923-28.

Temple ME, Nahata MC. Comparative palatability of 22 liquid antacid. Aliment Pharmacol Ther. 2000;14:421-25.

Sadia Nasim, et al. Liquid antacid: a comparative study on palatability and cost effectiveness. Pak J Med Sci 2012;28(1):183-186.

Rossett NE, Rice J. Duodenal ulcer producing obstructive jaundice. Gastroenterology 1954;26:490.

The United States pharmacopoeia. The national formulary, USP 22, NF 17, united states pharmacopoeial convention, inc., Rockville M.D.,1990, 1528.

Gadad AP, Dandagi PM, et al. Non-chewable antacid formulations: effect of different disintegrating agents on their acid neutralization properties. Indian J Pharm Sci. Mar-Apr 2006:269-73.

Ruff ME, Schotik DA, Bass JW, Vincent JM. Antimicrobial drug suspensions: a blind comparison of taste of fourteen common paediatric drugs. Paediatric Infect Dis J. 1991;10:30-33.

Mahadevan U, Kane S. American gastroenterological association institute medical position statement on the use of gastrointestinal medication in pregnancy. Gastroenterology 2006 Jul;131(1):282-87.