Wound healing property of paroxetine in immunosuppressed albino rats

Dwajani S, Ranjana Gurumurthy

Abstract


Background: The objectives of this study were to evaluate the wound healing activity of Paroxetine in different wound models in wistar rats and to study its effects on dexamethasone suppressed wound healing.

Methods: For assessment of wound healing activity, excision and incision wound models were used. Group I was assigned as control, orally, Group II received Paroxetine, i.p, Group III received Dexamethasone intramuscularly (i.m) and Group IV received Dexamethasone i.m and Paroxetine, i.p. Parameters observed were epithelization and wound contraction of excision model and breaking strength of incision wound model.

Results: In incision model, it was noted that the breaking strength was not significantly increased in paroxetine treated group when compared to control group. Paroxetine hastened the period of epithelization and the effect of dexamethasone was reversed by paroxetine in incision and excision models

Conclusion: It is concluded that Paroxetine could be an effective agent for healing wounds in immunocompromised patients.


Keywords


Paroxetine, Dexamethasone, Excision, Incision, Rats

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References


http://www.merriam-webster.com/dictionary/wound accessed on 10th July 2013.

http://en.wikipedia.org/wiki/Wound accessed on 10th July 2013.

Brown GL, Curtsinger LT, White M, Mitchell RO, Pietsch J, Nordquist R et al. Accelaration of tensile strength of incisions treated with EGF and TGFβ. Ann Surg. 1998a; 208: 778-792.

Ehrlich HP, Hunt TK. Effect of cortisone and vitamin A on wound healing. Ann Surg. 1968; 167:324-328.

Raju SS, Kulkarni DR. Vitamin A reverses the wound healing suppressant effect of cyclophosphamide. Ind J Pharmacol. 1986;18:154-157.

Lee KH. Studies on mechanism of action of salicylates III, effect of vitamin A on wound healing retardation of aspirin. J Pharma Sci. 1968a;57:1238-1240.

Myers KA, Marshall RE, Friedin J. Principles of pathology in surgery. Blackwell scientific Publications. 1980;58-62.

David EG, Armen HT, Ehrin J, Armstrong, April WM. Principles of pharmacology , the pathophysiologic basics of drug therapy. Second Edition. Lippioncott Williams and Wilking. 2008; 216.

Grahame DG, Aronson JK. Clinical Pharmacology and drig therapy. Third edition. Oxford University press.2002;490.

Alex Malinin, Benjamin O, Victor Serebruany. Treatment with selective serotonin reuptake inhibitors for enhancing wound healing. Medical hypothesis. 2004;63:103-109.

Farahani, Ramani MZ, Sadr Katayoun et.al. Fluoxetine enhances cutaneous wound healing in chemically stressed in wistar rats. Advances in skin and wound care. 2007;20(3):157-165.

Walter JB, Israel CT. Connective tissue: its normal structure and effects of disease . Walter and Isreal general pathology. Seventh edition. Chruchill Livingstone. 1996;103-16.

Cophen IK, Diegelmann RF, Crossland MC, Schwatz SI, Shires GT, Spencer FC, Husser WC. Wound care and wound healing.. Principles of surgery. Sixth edition. Mc Graw hill INC. 1994;279-304.

Iocono JA, Ehrlich HP, Leaper DJ, Harding KG. The biology of healing. Wounds biology and management. Oxford (UK). Oxford university press. 1998;11.

Shanbhag T, Shenoy S, et al. Wound healing profile of Tinospora Cardiofolia. Indian Drugs.2005;42:217-21.

Kesim M, Duman EN, et.al. The different roles of 5HT2 and 5HT3 receptors on antinociceptive effect of paroxetine in chemical stimuli in mice. J Pharamcol Sci. 2005;97(1):61-6.

Dwajani S, Tara VS. Michelica Champaca: Wound healing activity in immunosuppressed rats. Internet Journal of Alternative Medicine. 2009;7(2).

Ehrlich HP, Hunt TK. Effect of cortisone and anabolic steroids on tensile strength of healing wounds. Ann surg.1969;170:203-6.

Lee KH, Tang TG. Mechanism of action of retinyl compounds on wound healing II. Effect of active retinyl derivatives on granuloma formation. J Pharma Sci. 1970;59:1195-97.

Morton JP, Malone MH. Evaluation of vulnerary activity by an open wound procedure in rats. Arch Int Pharmacodyn. 1972;176:117-226.

Bairy KL, Rao CM. Wound healing profile of Ginkgo biloba. J Natural Remedies. 2001;1:25-7.

Shanbhag Tara V, Sharma C, Adiga S, Bairy KL, Shenoy S, Shenoy G. Wound healing activity of alcoholic extract of Kaempferia Galanga in wistar rats. Indian J of Physiol and Pharmacol. 2006;50(4):384-90.

Maiere CM, Chan PH. Role of superoxide dismutase in oxidative damage and neurodegenerative disorders. Neuroscientist. 2002; 8: 323-324.