Experimental evaluation of anticonvulsant effect of human placental extract in pentylenetetrazole induced convulsions in mice

Authors

  • Avanthi S. Department of Pharmacology, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar-505001, Andhra Pradesh, India
  • Pushpalatha Chinnam Department of Pharmacology, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar-505001, Andhra Pradesh, India
  • Gundappa S. Rao Department of Agada Tantra, Amrita School of Ayurveda, Amrita University, Amritapuri Campus, Kollam-690525, Kerala, India
  • Sam Pavan Kumar G. Department of Pharmacology, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar-505001, Andhra Pradesh, India
  • Mohd. Mohsin Department of Pharmacology, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar-505001, Andhra Pradesh, India

Keywords:

Anticonvulsant, Human placental extract (HPE), Sodium valproate, Pentylenetetrazole

Abstract

Background: Human placental extract (HPE) is used in different clinical conditions. Human placental extract (HPE), a folklore medicine, prepared from fresh, healthy human placenta has been in use, as single dose therapy in the treatment of epilepsy in some parts of India. Hence, present study was carried out to explore anticonvulsant property of Human placental extract (HPE) in Pentylenetetrazole (PTZ) induced convulsions in albino mice.

Methods: Effects of human placental extract (HPE) (1.0, 1.2 and 1.4 ml / 100 gm body weight) as test drug, sodium valproate (150 mg / kg body weight) as standard and distilled water as control were studied in pentylenetetrazole (PTZ) induced convulsions in albino mouse model. Failure to observe even a single episode of tonic spasm for 5 sec. duration for 1 hour was taken as index of anticonvulsant activity. Onset, duration, complete recovery from convulsion and percent protection was calculated and statistical analysis was carried out using student ‘t’ test.

Results: Pretreatment with human placental extract (HPE) administered in the dose of 1.0 ml / 100 gm body weight provided 33.33% and in the doses of 1.2 and 1.4 ml / 100 gm body weight and sodium valproate provided 100% protection from convulsions induced by Pentylenetetrazole in albino mice.

Conclusion: Human placental extract (HPE) has shown promising anticonvulsant effect on Pentylenetetrazole induced mouse model.

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Published

2017-02-01

How to Cite

S., A., Chinnam, P., Rao, G. S., G., S. P. K., & Mohsin, M. (2017). Experimental evaluation of anticonvulsant effect of human placental extract in pentylenetetrazole induced convulsions in mice. International Journal of Basic & Clinical Pharmacology, 2(5), 571–576. Retrieved from https://www.ijbcp.com/index.php/ijbcp/article/view/1322

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