Phenobarbitone induced drug reaction with eosinophilia and systemic symptoms (DRESS): a case report

Navreet K. Natt, Tarsem Singh, Harmanjit Singh, Manu Sharma, Gagandeep Singh


Drug reaction with eosinophilia and systemic symptoms (DRESS) is a life threatening cutaneous drug reaction with visceral involvement and hematological abnormalities. Being a rare side effect, it is often under-reported and misdiagnosed. The fatal adverse drug reaction is associated most commonly with aromatic anti-epileptics phenytoin, carbamazepine and less frequently with phenobarbitone. Here, we report a case of phenobarbitone induced DRESS in a 1 year old male child. He succumbed to fulminant hepatic failure inspite of being put on steroids, hepatoprotectives, antibiotics and ventilatory support.


Phenobarbitone, Adverse drug reactions, Anti-epileptics

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