Prevalence of G6PD deficiency versus oxidizing drugs: a survey in the tertiary care hospital

Authors

  • Rakesh R. Pathak Department of Pharmacology, C.U. Shah Medical College, Surendranagar 363001, India
  • Sunita B. Chhaiya Department of Pharmacology, C.U. Shah Medical College, Surendranagar 363001, India
  • Dimple S. Mehta Department of Pharmacology, C.U. Shah Medical College, Surendranagar 363001, India

Keywords:

G6PD deficiency, Oxidizing drug, Dapsone, Aspirin, Alcohol, Isoniazid

Abstract

Background: G6PD deficiency is distributed worldwide including India and is involved in accidental hemolysis and anemia by inadvertent use of oxidizing drugs. Awareness of community wise occurrence of G6PD deficiency can help in screening beforehand.

Methods: On 150 community wise classified, non-anemic, non- hemolysed (in recent past) visitors of pathological laboratory attached to C U Shah Medical College, Surendranagar, Gujarat, Crayman’s hemoglobin colorimetric kit (item no 700540) was used to estimate normal or below normal status of G6PD.

Results: 10 people (6.6% of population) were found deficient – 7 (4 male + 3 female) from Harijan community, 2 (1 male + 1 female) from Rabbari community and 1 (1 male + 0 female) from Lohana community.

Conclusions: While applying oxidizing drugs in a person of Harijan community (prevalence 7 out of total 26, i.e. 27%), extra caution is required, esp. if a person otherwise vulnerable (e.g. alcoholic). For other less represented communities, larger stratified sampling is required.

References

Babbitt GA. Inbreeding reduces power-law scaling in the distribution of fluctuating asymmetry: an explanation of the basis of developmental instability. Heredity 2006;97:258-68.

Beutler E. G6PD deficiency. Blood 1994;84:3613-36.

Beutler E, Duparc S; G6PD Deficiency Working Group. Glucose-6-Phosphate Dehydrogenase Deficiency and Antimalarial Drug Development. Am J Trop Med Hyg 2007;77:779-89.

Beutler E. Glucose-6-phosphate dehydrogenase deficiency: a historical perspective Blood 2008;111:16-24.

Bulletin of the Bihar Tribal Research Institute 1965;5:12.

Buyukokurogle ME, Altikat S, Ciftci M. The Effect of ethanol on Glucose 6-Phosphate Dehydrogenase Enzyme Activity from Human Erythrocyte in vitro and Rat Erythrocyte in vivo. Alcohol Alcohol 2002;37:327-9.

Dacie JV, Lewis SM. Practical Hematology, 9th Ed. Edinburgh: Churchill Livingstone; 2001.

Fredberg IM, Eisa AZ, Wolf K, editors. Fitzpatrick: Dermatology in general medicine. 5th. New York: McGraw-Hill; 1999. pp. 2791-2.

Hockwald RS, Arnold J, Clayman CB, Aling AS; Status of Primaquine : Toxicity of Primaquine in Nigros. JAMA 1952:149:1568.

Tantular IS, Kawamoto F. An improved, simple screening method for detection of glucose-6-phosphate dehydrogenase deficiency. Trop Med Int Health 2003;8:569-74.

Jyothi P, Riyaz N, Nanadkumar G, Binitha MP. A Study of Oxidative Stress in Paucibacillary and Multibacillary Leprosy. Ind J Dermatol Venereol Leprol 2008;74:80.

Loguercio C, Clot P, Albano E, Argenzio F, Grella A, De Girolamo V, et al. Free radicals and not acetaldehyde influence the circulating levels of glutathione after acute or chronic alcohol abuse: in vivo and in vitro studies. Ital J Gastroenterol Hepatol 1997;29:168-73.

Mandell GL, Bennett JE, Dolin R, editors. Mandell, Douglas, and Bennett's principles and practice of infectious diseases. 5th ed. New York: Elsevier/Churchill Livingstone; 2005. p. 523.

Markic J, Krželj V, Markotić A, Marušić E, Stričević L, Zanchi J, Bošnjak N, Sapunar A. High Incidence of Glucose-6-phosphate Dehydrogenase Deficiency in Croatian Island Isolate: Example from Vis Island, Croatia. Croat Med J 2006;47:566-70.

Melrose D. Double deprivation public and private drug distribution from the perspective of the third world's poor. World Dev 1983;11:181-6.

National Medicine List of India – 2011. Available at http://ebookbrowse.com/list-of-essential-medicine-india-pdf-d312718262. Accessed 16 January 2013.

Noori-Daloii MR. M. Daneshpajooh. Molecular basis of g6pd deficiency: current status and its perspective. Acta Medica Iranica 2008;46:167-182.

Park K. Park's Textbook of Preventive and Social Medicine. 19th ed. Jabalpur: M/s Banarasidas Bhanot Publishers; 2007.

Program for Sample Size Estimation. Available at http://www.stattools.net/SSizprop_Pgm.php. Accessed 20 January 2013.

Rehan HS, Singh C, Tripathi CD, Kela AK. Study of drug utilization pattern in dental OPD at tertiary care teaching hospital. Indian J Dent Res 2001;12:51-6.

Relling MV, Giacomini KM. Pharmacogenetics. In: Brenton LL, Lazo JS, Parker KL, editors. Goodman & Gilman’s. The pharmacological basis of therapeutics, 12th ed. New York: McGraw Hill; 2011:145-68.

Sahasrabudhe T. Is Supplementation of Pyridoxine A Necessary Adjunct with Daily First Line TB Chemotherapy Regimen for Indian Patients? Res J Pharm Biological Chemical Sci 2012;3:1042.

Singh N, Dubey S, Chinnaraj S, Golani A, Maitra A. Study of NAT2 gene polymorphisms in an Indian population: Their association with plasma isoniazid concentration in a cohort of tuberculosis patients. Molecular Diagnosis and Therapy 2009;13:49-58.

Sood SK, Rusia U. Annals of National Academy of Medical Sciences India 1986;22:235.

Stalnikowicz R, Amitai Y, Bentur Y. Aphrodisiac Drug‐Induced Hemolysis. J Toxicol Clin Toxicol 2004;42:313-6.

The Economic Times, 17/03/2008.

Tyulina OV, Huentelman MJ, Prokopieva VD, Boldyrev AA, Johnson P. Does ethanol metabolism affect erythrocyte hemolysis? Biochim Biophys Acta 2000;1535:69-77.

Vallely A, Vallely L, Changalucha J, Greenwood B, Chandramohan D. Intermittent preventive treatment for malaria in pregnancy in Africa: What's new, what's needed? Malar J 2007;6:16.

World Health Organization. Surveillance standards for antimicrobial resistance, WHO/CDS/CSR/DRS/2001/5. Available at http://www.who.int/drugresistance/publications/WHO_CDS_CSR_DRS_2001_5/en/. Accessed 20 January 2013.

World Health Organization. Introduction to drug utilization research. Geneva: World Health Organization; 2003.

Lee R, Foerster J, Lukens J, Paraskevas F, Greer J, Rodgers G. Wintrobe's clinical hematology, 10th ed. Baltimore: Lippincott Williams & Wilkins; 1999:1176-90.

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Published

2017-01-30

How to Cite

Pathak, R. R., Chhaiya, S. B., & Mehta, D. S. (2017). Prevalence of G6PD deficiency versus oxidizing drugs: a survey in the tertiary care hospital. International Journal of Basic & Clinical Pharmacology, 2(2), 170–176. Retrieved from https://www.ijbcp.com/index.php/ijbcp/article/view/1230

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Original Research Articles