Published: 2017-01-28

Neuroprotective effect of secretin in chronic hypoxia induced neurodegeneration in rats

Gowtham Padmanaban, M. K. Kayalvizhi, Kalyanasundaram Kasiviswanathan, Ruckmani Arunachalam, Vishnu Kumar Urkavalan


Background: Hypoxia is a condition in any stage in the delivery of oxygen to cells which include decreased partial pressures of oxygen, less diffusion of oxygen in the lungs, insufficient hemoglobin, inefficient blood flow to the end tissue, and breathing rhythm. Secretin is an amino acid which plays proper functioning of gastro intestinal system.

Methods: The current study was conducted to evaluvate the effect of exogenously administrated secretin on chronic hypoxic damage of brain in rat model. Experimental design consists of control animals, Control animals + secretin hypoxia exposed animals; hypoxia exposed animals +secretin (20ng/

Results: The results of this study point to a possible role of Secretin as neuroprotectant.

Conclusions: Further research on secretin needs to be conducted in order to confirm the deductions made by this study.


Anti-oxidant, Hypoxia, Secretin, Hemoglobin, Neuroprotectant

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