Gabapentin for post-operative nausea and vomiting: a pilot study

Authors

  • Vikram Bhandari Department of Pharmacology,HIMS, Dehradun, Uttarakhand, India Department of Pharmacology SGRDIMSR, Amritsar, Punjab, India
  • Dilip C. Dhasmana Department of Pharmacology,HIMS, Dehradun, Uttarakhand, India
  • Jagdish P. Sharma Department of Anaesthesia,HIMS, Dehradun, Uttarakhand, India
  • Praveendra K. Sachan Department of Surgery, HIMS, Dehradun, Uttarakhand, India
  • Aditi Chaturvedi Department of Pharmacology,HIMS, Dehradun, Uttarakhand, India
  • Sheveta Dureja Department of Physiology, Chintpurni Medical College, Pathankot, Punjab, India

Keywords:

Gabapentin, Post-operative nausea and vomiting, Cholecystectomy

Abstract

Background: Gabapentin has been used in perioperative setting for the management of post-operative pain for surgery performed under general anaesthesia. Post-operative nausea and vomiting (PONV) even with the use of newer agents remains a major problem. The primary aim of this study was to see if gabapentin use decreased PONV.

Methods: A total of 40 patients undergoing elective laparoscopic cholecystectomy under general anesthesia with standardized premedication and anesthetics were randomized to receive gabapentin or a matching placebo. The patients in Group I received gabapentin 600 mg orally 2 hrs before surgery and 12 hrs after the first dose. The patients in Group II received a matching placebo orally 2 hrs before surgery and 12hrs after the first dose. Patients in both groups received diclofenac sodium 75 mg i.m b.i.d for pain and ondensetron 4 mg i.v for PONV. Additional doses were given on demand and recorded. The treatment was double blinded.

Results: The present study did not find significant reduction in PONV score and antiemetic consumption in gabapentin group when compared to a placebo for a period of 24 hrs.

Conclusions: Gabapentin in the doses used was found to ineffective in post-operative nausea and vomiting in patients undergoing planned laparoscopic cholecystectomy with standardized pre-anaesthetic and anaesthetic medication.

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Published

2017-01-25

How to Cite

Bhandari, V., Dhasmana, D. C., Sharma, J. P., Sachan, P. K., Chaturvedi, A., & Dureja, S. (2017). Gabapentin for post-operative nausea and vomiting: a pilot study. International Journal of Basic & Clinical Pharmacology, 3(4), 627–631. Retrieved from https://www.ijbcp.com/index.php/ijbcp/article/view/1043

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Original Research Articles