Assessment of oral hypoglycaemic activity of water soluble extract of aloe vera and its interaction with glipizide in alloxan induced diabetic Wistar Rats

Authors

  • Vikalp Tiwari Department of Pharmacology, M.G.M. Medical College, Indore, Madhya Pradesh, India
  • Gopal Gudsurkar Department of Pharmacology, M.G.M. Medical College, Indore, Madhya Pradesh, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20173149

Keywords:

Alloxan, Aloe vera, Glipizide, Hypoglycaemia

Abstract

Background: Assessment of oral hypoglycaemic activity of water soluble extract of Aloe vera and its interaction with Glipizide in Alloxan induced diabetic Wistar rats.

Methods: Under standard condition of testing, alloxan induced diabetic rats were kept in fasting state of 8 hours and then glucose in dose of 1gm/kg was given PO by feeding tube. There after water soluble extract of aloe vera in dose of 200mg/kg BW dissolves in 1ml of Distilled water (DW) to test group 1, Glipizide in dose of 2.5mg/kg BW dissolved in 1ml DW was given to standard group. Test group 2 received combination of Aloe vera 200mg/kg BW and Glipizide in dose of 2.5mg/kg BW dissolved in 1ml Dw. Control group received 1ml of Distilled water. Blood sugars levels of all Rats in each group were checked with Glucometer.

Results: Clinically and statistically significant glucose lowering effect was observed in groups administered with Aloe vera and better results were observed in group receiving Aloe vera and Glipizide combination.

Conclusions: Water soluble extract of aloe vera has significant hypoglycaemic activity and the results showed that co-administration of Aloe vera and Glipizide has superior hypoglycaemic activity compared to Aloe vera and Glipizide given Individually.

References

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Published

2017-07-22

How to Cite

Tiwari, V., & Gudsurkar, G. (2017). Assessment of oral hypoglycaemic activity of water soluble extract of aloe vera and its interaction with glipizide in alloxan induced diabetic Wistar Rats. International Journal of Basic & Clinical Pharmacology, 6(8), 1917–1920. https://doi.org/10.18203/2319-2003.ijbcp20173149

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Original Research Articles